TY - JOUR
T1 - An intercross population study reveals genes associated with body size and plumage color in ducks
AU - Zhou, Zhengkui
AU - Li, Ming
AU - Cheng, Hong
AU - Fan, Wenlei
AU - Yuan, Zhengrong
AU - Gao, Qiang
AU - Xu, Yaxi
AU - Guo, Zhanbao
AU - Zhang, Yunsheng
AU - Hu, Jian
AU - Liu, Hehe
AU - Liu, Dapeng
AU - Chen, Weihuang
AU - Zheng, Zhuqing
AU - Jiang, Yong
AU - Wen, Zhiguo
AU - Liu, Yongming
AU - Chen, Hua
AU - Xie, Ming
AU - Zhang, Qi
AU - Huang, Wei
AU - Wang, Wen
AU - Hou, Shuisheng
AU - Jiang, Yu
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Comparative population genomics offers an opportunity to discover the signatures of artificial selection during animal domestication, however, their function cannot be directly revealed. We discover the selection signatures using genome-wide comparisons among 40 mallards, 36 indigenous-breed ducks, and 30 Pekin ducks. Then, the phenotypes are fine-mapped based on resequencing of 1026 ducks from an F2 segregating population generated by wild × domestic crosses. Interestingly, the two key economic traits of Pekin duck are associated with two selective sweeps with fixed mutations. A novel intronic insertion most possibly leads to a splicing change in MITF accounted for white duck down feathers. And a putative long-distance regulatory mutation causes continuous expression of the IGF2BP1 gene after birth which increases body size by 15% and feed efficiency by 6%. This study provides new insights into genotype-phenotype associations in animal research and constitutes a promising resource on economically important genes in fowl.
AB - Comparative population genomics offers an opportunity to discover the signatures of artificial selection during animal domestication, however, their function cannot be directly revealed. We discover the selection signatures using genome-wide comparisons among 40 mallards, 36 indigenous-breed ducks, and 30 Pekin ducks. Then, the phenotypes are fine-mapped based on resequencing of 1026 ducks from an F2 segregating population generated by wild × domestic crosses. Interestingly, the two key economic traits of Pekin duck are associated with two selective sweeps with fixed mutations. A novel intronic insertion most possibly leads to a splicing change in MITF accounted for white duck down feathers. And a putative long-distance regulatory mutation causes continuous expression of the IGF2BP1 gene after birth which increases body size by 15% and feed efficiency by 6%. This study provides new insights into genotype-phenotype associations in animal research and constitutes a promising resource on economically important genes in fowl.
UR - https://www.scopus.com/pages/publications/85050384614
U2 - 10.1038/s41467-018-04868-4
DO - 10.1038/s41467-018-04868-4
M3 - 文章
C2 - 30018292
AN - SCOPUS:85050384614
SN - 2041-1723
VL - 9
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 2648
ER -