An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels

Ding Li; Xiaoping Li; Honglong Chang

doi:10.1109/MEMSYS.2018.8346775

An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels

Ding Li
, Xiaoping Li
, Honglong Chang

机电学院

Northwestern Polytechnical University Xian

科研成果: 书/报告/会议事项章节 › 会议稿件 › 同行评审

4 引用（Scopus）

摘要

This paper reports an integrated ion chromatography microchip for the fast, low-cost and reproducible measurement of glycated hemoglobin (HbA_lc). Except the pump, all chromatography components including four membrane microvalves, a packed column, two porous frits and an optical detector cell are integrated on the single chip. In the experiments, the HbA_1c levels can be precisely measured with fewer samples (1 μl) in a shorter period of time (5 mins) compared to the state-of-the-art nanoflow liquid chromatography (LC) microchip (4 μl & 50 mins). The coefficient of variation (c.v.) for three consecutive measurements of HbA_1c calibrators was from 3.1% to 9.0%, indicating that the measurement was reproducible and the chip can be used for point-of-care diabetes diagnosis.

源语言	英语
主期刊名	2018 IEEE Micro Electro Mechanical Systems, MEMS 2018
出版商	Institute of Electrical and Electronics Engineers Inc.
页	1189-1192
页数	4
ISBN（电子版）	9781538647820
DOI	https://doi.org/10.1109/MEMSYS.2018.8346775
出版状态	已出版 - 24 4月 2018
活动	31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018 - Belfast, 英国期限: 21 1月 2018 → 25 1月 2018

出版系列

姓名	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
卷	2018-January
ISSN（印刷版）	1084-6999

会议

会议	31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018
国家/地区	英国
市	Belfast
时期	21/01/18 → 25/01/18

联合国可持续发展目标

此成果有助于实现下列可持续发展目标：

可持续发展目标 3 良好健康与福祉

访问文件

10.1109/MEMSYS.2018.8346775

其它文件与链接

链接到 Scopus 的出版物

引用此

Li, D., Li, X., & Chang, H. (2018). An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels. 在 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018 (页码 1189-1192). (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); 卷 2018-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMSYS.2018.8346775

Li, Ding ; Li, Xiaoping ; Chang, Honglong. / An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels. 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Institute of Electrical and Electronics Engineers Inc., 2018. 页码 1189-1192 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

@inproceedings{2a8c3474d5504fe9bff9ea779ab58815,

title = "An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels",

abstract = "This paper reports an integrated ion chromatography microchip for the fast, low-cost and reproducible measurement of glycated hemoglobin (HbAlc). Except the pump, all chromatography components including four membrane microvalves, a packed column, two porous frits and an optical detector cell are integrated on the single chip. In the experiments, the HbA1c levels can be precisely measured with fewer samples (1 μl) in a shorter period of time (5 mins) compared to the state-of-the-art nanoflow liquid chromatography (LC) microchip (4 μl \& 50 mins). The coefficient of variation (c.v.) for three consecutive measurements of HbA1c calibrators was from 3.1\% to 9.0\%, indicating that the measurement was reproducible and the chip can be used for point-of-care diabetes diagnosis.",

author = "Ding Li and Xiaoping Li and Honglong Chang",

note = "Publisher Copyright: {\textcopyright} 2018 IEEE.; 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018 ; Conference date: 21-01-2018 Through 25-01-2018",

year = "2018",

month = apr,

day = "24",

doi = "10.1109/MEMSYS.2018.8346775",

language = "英语",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "1189--1192",

booktitle = "2018 IEEE Micro Electro Mechanical Systems, MEMS 2018",

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Li, D, Li, X & Chang, H 2018, An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels. 在 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), 卷 2018-January, Institute of Electrical and Electronics Engineers Inc., 页码 1189-1192, 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018, Belfast, 英国, 21/01/18. https://doi.org/10.1109/MEMSYS.2018.8346775

An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels. / Li, Ding; Li, Xiaoping; Chang, Honglong.
2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Institute of Electrical and Electronics Engineers Inc., 2018. 页码 1189-1192 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); 卷 2018-January).

科研成果: 书/报告/会议事项章节 › 会议稿件 › 同行评审

TY - GEN

T1 - An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels

AU - Li, Ding

AU - Li, Xiaoping

AU - Chang, Honglong

PY - 2018/4/24

Y1 - 2018/4/24

N2 - This paper reports an integrated ion chromatography microchip for the fast, low-cost and reproducible measurement of glycated hemoglobin (HbAlc). Except the pump, all chromatography components including four membrane microvalves, a packed column, two porous frits and an optical detector cell are integrated on the single chip. In the experiments, the HbA1c levels can be precisely measured with fewer samples (1 μl) in a shorter period of time (5 mins) compared to the state-of-the-art nanoflow liquid chromatography (LC) microchip (4 μl & 50 mins). The coefficient of variation (c.v.) for three consecutive measurements of HbA1c calibrators was from 3.1% to 9.0%, indicating that the measurement was reproducible and the chip can be used for point-of-care diabetes diagnosis.

AB - This paper reports an integrated ion chromatography microchip for the fast, low-cost and reproducible measurement of glycated hemoglobin (HbAlc). Except the pump, all chromatography components including four membrane microvalves, a packed column, two porous frits and an optical detector cell are integrated on the single chip. In the experiments, the HbA1c levels can be precisely measured with fewer samples (1 μl) in a shorter period of time (5 mins) compared to the state-of-the-art nanoflow liquid chromatography (LC) microchip (4 μl & 50 mins). The coefficient of variation (c.v.) for three consecutive measurements of HbA1c calibrators was from 3.1% to 9.0%, indicating that the measurement was reproducible and the chip can be used for point-of-care diabetes diagnosis.

UR - https://www.scopus.com/pages/publications/85047003951

U2 - 10.1109/MEMSYS.2018.8346775

DO - 10.1109/MEMSYS.2018.8346775

M3 - 会议稿件

AN - SCOPUS:85047003951

T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

SP - 1189

EP - 1192

BT - 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018

Y2 - 21 January 2018 through 25 January 2018

ER -

Li D, Li X, Chang H. An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels. 在 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Institute of Electrical and Electronics Engineers Inc. 2018. 页码 1189-1192. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMSYS.2018.8346775

An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels

摘要

出版系列

会议

联合国可持续发展目标

访问文件

其它文件与链接

学术指纹

引用此