胶原/HA复合涂层多孔钛的细胞响应行为

In order to improve the surface activity and biocompatibility of the medical porous titanium, sintered fibrous porous titanium was used as a carrier, the hydroxyapatite (HA) was deposited by alkaline heat treatment and simulated body fluids, then the water soluble collagen was coated on the HA surface to form collagen/HA composite coated porous titanium with three-dimensional penetrating pore structure. The surface morphology and chemical composition of collagen/HA composite coating were studied, the formation mechanism of collagen/HA composite coating was discussed. The cytotoxicity in vitro was tested and the cell response behavior on porous titanium surface was analyzed. The results show that the collagen/HA composite coating was uniformly adhered on the surface of the titanium fiber, the microcracks on the surface of HA coating can be repaired by collagen filling, which improves adhesion, proliferation, differentiation of mouse previous osteoblasts and the inter-fiber growth. HA/collagen composite coating shows an improved cellular response and an promotion of fixation between early bone and implant.