TY - JOUR
T1 - Synthesis of α-hydroxy-ω-aminotelechelic polypeptide from α-amino acid N-carboxyanhydrides catalyzed by alkali-metal borohydrides
AU - Peng, Hui
AU - Chen, Wan Li
AU - Kong, Jie
AU - Shen, Zhi Quan
AU - Ling, Jun
PY - 2014/6
Y1 - 2014/6
N2 - It is reported that alkali-metal borohydrides (MBH4, M = Li, Na and K) are efficient catalysts for ring opening polymerization (ROP) of α-amino acid N-carboxyanhydrides (NCAs). Polypeptides are prepared in quantitative yields with relatively narrow molecular weight distributions (MWDs = 1.1~1.5) which depend on the reaction temperature. End groups of the produced polypeptide are studied in detail by MALDI-ToF MS, 1H-NMR, 13C-NMR, 1H-1H COSY and 1H-13C HMQC analyses. The results indicate that α-hydroxy-ω-aminotelechelic polypeptides are formed which are suitable for postpolymerization functionalization.
AB - It is reported that alkali-metal borohydrides (MBH4, M = Li, Na and K) are efficient catalysts for ring opening polymerization (ROP) of α-amino acid N-carboxyanhydrides (NCAs). Polypeptides are prepared in quantitative yields with relatively narrow molecular weight distributions (MWDs = 1.1~1.5) which depend on the reaction temperature. End groups of the produced polypeptide are studied in detail by MALDI-ToF MS, 1H-NMR, 13C-NMR, 1H-1H COSY and 1H-13C HMQC analyses. The results indicate that α-hydroxy-ω-aminotelechelic polypeptides are formed which are suitable for postpolymerization functionalization.
KW - Alkali-metal borohydride
KW - End group functionalization
KW - Polypeptide
KW - Α-Amino acid N-carboxyanhydride
UR - http://www.scopus.com/inward/record.url?scp=84905567562&partnerID=8YFLogxK
U2 - 10.1007/s10118-014-1445-6
DO - 10.1007/s10118-014-1445-6
M3 - 文章
AN - SCOPUS:84905567562
SN - 0256-7679
VL - 32
SP - 743
EP - 750
JO - Chinese Journal of Polymer Science (English Edition)
JF - Chinese Journal of Polymer Science (English Edition)
IS - 6
ER -