Synthesis, crystal structures and in vitro antitumor activities of some arylantimony derivatives of analogues of demethylcantharimide

Guo Cang Wang; Jian Xiao; Lin Yu; Jin Shan Li; Jing Rong Cui; Rui Qing Wang; Fu Xiang Ran

doi:10.1016/j.jorganchem.2004.02.015

Synthesis, crystal structures and in vitro antitumor activities of some arylantimony derivatives of analogues of demethylcantharimide

Guo Cang Wang
, Jian Xiao
, Lin Yu
, Jin Shan Li
, Jing Rong Cui
, Rui Qing Wang
, Fu Xiang Ran

Nankai University
Peking University

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A series of novel arylantimony derivatives of analogues of demethylcantharimide with the formulae Ar_nSbL_(5-n) and Ar_nSbL^′_(5-n) (LH=N-hydroxy-demethyldehydrogencantharimide, L^′ H=N-hydroxy-demethylcantharimide, n=3, 4; Ar=C₆H₅, 4-CH₃C₆H₄, 3-CH₃C₆H₄, 2-CH₃C₆ H₄, 4-ClC₆H₄, 4-FC₆H₄) were synthesized and characterized by elemental analysis, IR, ¹H NMR and mass spectroscopy. The crystal structures of (C₆H₅)₄SbL, (4-CH₃C₆H₄)₃SbL₂ and (3-CH₃C₆H₄)₃ SbL^′₂ were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against six cancer cells are reported.

Original language	English
Pages (from-to)	1631-1638
Number of pages	8
Journal	Journal of Organometallic Chemistry
Volume	689
Issue number	9
DOIs	https://doi.org/10.1016/j.jorganchem.2004.02.015
State	Published - 1 May 2004
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antimony
Antitumor activity
Crystal structures
Demethylcantharimide

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10.1016/j.jorganchem.2004.02.015

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@article{46f560bf2ada4501bae2ff412719d2fb,

title = "Synthesis, crystal structures and in vitro antitumor activities of some arylantimony derivatives of analogues of demethylcantharimide",

abstract = "A series of novel arylantimony derivatives of analogues of demethylcantharimide with the formulae ArnSbL(5-n) and ArnSbL′(5-n) (LH=N-hydroxy-demethyldehydrogencantharimide, L′ H=N-hydroxy-demethylcantharimide, n=3, 4; Ar=C6H5, 4-CH3C6H4, 3-CH3C6H4, 2-CH3C6 H4, 4-ClC6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectroscopy. The crystal structures of (C6H5)4SbL, (4-CH3C6H4)3SbL2 and (3-CH3C6H4)3 SbL′2 were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against six cancer cells are reported.",

keywords = "Antimony, Antitumor activity, Crystal structures, Demethylcantharimide",

author = "Wang, \{Guo Cang\} and Jian Xiao and Lin Yu and Li, \{Jin Shan\} and Cui, \{Jing Rong\} and Wang, \{Rui Qing\} and Ran, \{Fu Xiang\}",

year = "2004",

month = may,

day = "1",

doi = "10.1016/j.jorganchem.2004.02.015",

language = "英语",

volume = "689",

pages = "1631--1638",

journal = "Journal of Organometallic Chemistry",

issn = "0022-328X",

publisher = "Elsevier B.V.",

number = "9",

}

TY - JOUR

T1 - Synthesis, crystal structures and in vitro antitumor activities of some arylantimony derivatives of analogues of demethylcantharimide

AU - Wang, Guo Cang

AU - Xiao, Jian

AU - Yu, Lin

AU - Li, Jin Shan

AU - Cui, Jing Rong

AU - Wang, Rui Qing

AU - Ran, Fu Xiang

PY - 2004/5/1

Y1 - 2004/5/1

N2 - A series of novel arylantimony derivatives of analogues of demethylcantharimide with the formulae ArnSbL(5-n) and ArnSbL′(5-n) (LH=N-hydroxy-demethyldehydrogencantharimide, L′ H=N-hydroxy-demethylcantharimide, n=3, 4; Ar=C6H5, 4-CH3C6H4, 3-CH3C6H4, 2-CH3C6 H4, 4-ClC6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectroscopy. The crystal structures of (C6H5)4SbL, (4-CH3C6H4)3SbL2 and (3-CH3C6H4)3 SbL′2 were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against six cancer cells are reported.

AB - A series of novel arylantimony derivatives of analogues of demethylcantharimide with the formulae ArnSbL(5-n) and ArnSbL′(5-n) (LH=N-hydroxy-demethyldehydrogencantharimide, L′ H=N-hydroxy-demethylcantharimide, n=3, 4; Ar=C6H5, 4-CH3C6H4, 3-CH3C6H4, 2-CH3C6 H4, 4-ClC6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectroscopy. The crystal structures of (C6H5)4SbL, (4-CH3C6H4)3SbL2 and (3-CH3C6H4)3 SbL′2 were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against six cancer cells are reported.

KW - Antimony

KW - Antitumor activity

KW - Crystal structures

KW - Demethylcantharimide

UR - https://www.scopus.com/pages/publications/1842716619

U2 - 10.1016/j.jorganchem.2004.02.015

DO - 10.1016/j.jorganchem.2004.02.015

M3 - 文章

AN - SCOPUS:1842716619

SN - 0022-328X

VL - 689

SP - 1631

EP - 1638

JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

IS - 9

ER -

Synthesis, crystal structures and in vitro antitumor activities of some arylantimony derivatives of analogues of demethylcantharimide

Abstract

UN SDGs

Keywords

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