Synthesis, characterization and in vitro antitumor activity of some arylbismuth triphenylgermylpropionates and crystal structures

Lin Yu; Yong Qiang Ma; Guo Cang Wang; Jin Shan Li; Guan Hua Du; Juan Juan Hu

doi:10.1016/S0022-328X(03)00547-3

Synthesis, characterization and in vitro antitumor activity of some arylbismuth triphenylgermylpropionates and crystal structures

Lin Yu
, Yong Qiang Ma
, Guo Cang Wang
, Jin Shan Li
, Guan Hua Du
, Juan Juan Hu

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A series of novel arylbismuth(V) triphenylgermylpropionates with the formula Ar₃Bi(O₂CCHR¹ CHR²GePh₃)₂ (R¹=H, CH₃; R²=H, Ph; Ar=Ph, 4-CH₃C₆H₄, 4-FC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄) were synthesized and characterized by elemental analysis, IR, ¹H-NMR and mass spectroscopy. The crystal structures of (4-BrC₆H₄) ₃Bi(O₂CCH₂CH₂ GePh₃)₂ and (4-BrC₆H₄) ₃Bi[O₂CCH(CH₃)CH₂ GePh₃]₂ were determined by X-ray diffraction. Three human neoplastic cell lines (HCT-8, Bel-7402 and KB) were used to screen these compounds. The results indicate that some compounds at 5 μM show good in vitro antitumor activities.

Original language	English
Pages (from-to)	173-180
Number of pages	8
Journal	Journal of Organometallic Chemistry
Volume	679
Issue number	2
DOIs	https://doi.org/10.1016/S0022-328X(03)00547-3
State	Published - 15 Aug 2003
Externally published	Yes

Keywords

Antitumor activity
Bismuth
Crystal structures
Germanium

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10.1016/S0022-328X(03)00547-3

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@article{bf9e62123f5f47dfb94ac973204e9d90,

title = "Synthesis, characterization and in vitro antitumor activity of some arylbismuth triphenylgermylpropionates and crystal structures",

abstract = "A series of novel arylbismuth(V) triphenylgermylpropionates with the formula Ar3Bi(O2CCHR1 CHR2GePh3)2 (R1=H, CH3; R2=H, Ph; Ar=Ph, 4-CH3C6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4) were synthesized and characterized by elemental analysis, IR, 1H-NMR and mass spectroscopy. The crystal structures of (4-BrC6H4) 3Bi(O2CCH2CH2 GePh3)2 and (4-BrC6H4) 3Bi[O2CCH(CH3)CH2 GePh3]2 were determined by X-ray diffraction. Three human neoplastic cell lines (HCT-8, Bel-7402 and KB) were used to screen these compounds. The results indicate that some compounds at 5 μM show good in vitro antitumor activities.",

keywords = "Antitumor activity, Bismuth, Crystal structures, Germanium",

author = "Lin Yu and Ma, \{Yong Qiang\} and Wang, \{Guo Cang\} and Li, \{Jin Shan\} and Du, \{Guan Hua\} and Hu, \{Juan Juan\}",

year = "2003",

month = aug,

day = "15",

doi = "10.1016/S0022-328X(03)00547-3",

language = "英语",

volume = "679",

pages = "173--180",

journal = "Journal of Organometallic Chemistry",

issn = "0022-328X",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Synthesis, characterization and in vitro antitumor activity of some arylbismuth triphenylgermylpropionates and crystal structures

AU - Yu, Lin

AU - Ma, Yong Qiang

AU - Wang, Guo Cang

AU - Li, Jin Shan

AU - Du, Guan Hua

AU - Hu, Juan Juan

PY - 2003/8/15

Y1 - 2003/8/15

N2 - A series of novel arylbismuth(V) triphenylgermylpropionates with the formula Ar3Bi(O2CCHR1 CHR2GePh3)2 (R1=H, CH3; R2=H, Ph; Ar=Ph, 4-CH3C6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4) were synthesized and characterized by elemental analysis, IR, 1H-NMR and mass spectroscopy. The crystal structures of (4-BrC6H4) 3Bi(O2CCH2CH2 GePh3)2 and (4-BrC6H4) 3Bi[O2CCH(CH3)CH2 GePh3]2 were determined by X-ray diffraction. Three human neoplastic cell lines (HCT-8, Bel-7402 and KB) were used to screen these compounds. The results indicate that some compounds at 5 μM show good in vitro antitumor activities.

AB - A series of novel arylbismuth(V) triphenylgermylpropionates with the formula Ar3Bi(O2CCHR1 CHR2GePh3)2 (R1=H, CH3; R2=H, Ph; Ar=Ph, 4-CH3C6H4, 4-FC6H4, 4-ClC6H4, 4-BrC6H4) were synthesized and characterized by elemental analysis, IR, 1H-NMR and mass spectroscopy. The crystal structures of (4-BrC6H4) 3Bi(O2CCH2CH2 GePh3)2 and (4-BrC6H4) 3Bi[O2CCH(CH3)CH2 GePh3]2 were determined by X-ray diffraction. Three human neoplastic cell lines (HCT-8, Bel-7402 and KB) were used to screen these compounds. The results indicate that some compounds at 5 μM show good in vitro antitumor activities.

KW - Antitumor activity

KW - Bismuth

KW - Crystal structures

KW - Germanium

UR - https://www.scopus.com/pages/publications/0042074667

U2 - 10.1016/S0022-328X(03)00547-3

DO - 10.1016/S0022-328X(03)00547-3

M3 - 文章

AN - SCOPUS:0042074667

SN - 0022-328X

VL - 679

SP - 173

EP - 180

JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

IS - 2

ER -

Synthesis, characterization and in vitro antitumor activity of some arylbismuth triphenylgermylpropionates and crystal structures

Abstract

Keywords

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