Synthesis and stimulus-responsive micellization of a well-defined H-shaped terpolymer

Cheng Guang Mu; Xiao Dong Fan; Wei Tian; Yang Bai; Zhen Yang; Wei Wei Fan; Heng Chen

doi:10.1039/c2py20586f

Synthesis and stimulus-responsive micellization of a well-defined H-shaped terpolymer

Cheng Guang Mu, Xiao Dong Fan, Wei Tian, Yang Bai, Zhen Yang, Wei Wei Fan, Heng Chen

School of Chemistry and Chemical Engineering

Northwestern Polytechnical University Xian

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We describe the synthesis and self-assembly of a well-defined H-shaped terpolymer in this paper. A block copolymer of poly(ethylene glycol) (PEG) and poly(N,N-dimethylaminoethyl methacrylate) (PDMA), which bears an azido group at the diblock junction (PEG-N ₃(-PDMA)) was first prepared by atom transfer radical polymerization. Then, an alkynyl-terminated narrow distributed polytetrahydrofuran (PTHF-Alk) was synthesized as another building block via cationic ring opening polymerization. The well-defined H-shaped terpolymer was afforded by clicking PEG-N ₃(-PDMA) onto both chain-ends of PTHF-Alk. This H-shaped terpolymer can self-assemble into micelles with different sizes and morphologies at various solution pH values. The micellar size also exhibits temperature-dependence at pH 7.4 and 9.2. The variation of size and morphology of the micelles with the solution pH and temperature is ascribed to the pH- and thermo-responsive properties of the PDMA block.

Original language	English
Pages (from-to)	3330-3339
Number of pages	10
Journal	Polymer Chemistry
Volume	3
Issue number	12
DOIs	https://doi.org/10.1039/c2py20586f
State	Published - Dec 2012

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title = "Synthesis and stimulus-responsive micellization of a well-defined H-shaped terpolymer",

abstract = "We describe the synthesis and self-assembly of a well-defined H-shaped terpolymer in this paper. A block copolymer of poly(ethylene glycol) (PEG) and poly(N,N-dimethylaminoethyl methacrylate) (PDMA), which bears an azido group at the diblock junction (PEG-N 3(-PDMA)) was first prepared by atom transfer radical polymerization. Then, an alkynyl-terminated narrow distributed polytetrahydrofuran (PTHF-Alk) was synthesized as another building block via cationic ring opening polymerization. The well-defined H-shaped terpolymer was afforded by clicking PEG-N 3(-PDMA) onto both chain-ends of PTHF-Alk. This H-shaped terpolymer can self-assemble into micelles with different sizes and morphologies at various solution pH values. The micellar size also exhibits temperature-dependence at pH 7.4 and 9.2. The variation of size and morphology of the micelles with the solution pH and temperature is ascribed to the pH- and thermo-responsive properties of the PDMA block.",

author = "Mu, {Cheng Guang} and Fan, {Xiao Dong} and Wei Tian and Yang Bai and Zhen Yang and Fan, {Wei Wei} and Heng Chen",

year = "2012",

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doi = "10.1039/c2py20586f",

language = "英语",

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T1 - Synthesis and stimulus-responsive micellization of a well-defined H-shaped terpolymer

AU - Mu, Cheng Guang

AU - Fan, Xiao Dong

AU - Tian, Wei

AU - Bai, Yang

AU - Yang, Zhen

AU - Fan, Wei Wei

AU - Chen, Heng

PY - 2012/12

Y1 - 2012/12

N2 - We describe the synthesis and self-assembly of a well-defined H-shaped terpolymer in this paper. A block copolymer of poly(ethylene glycol) (PEG) and poly(N,N-dimethylaminoethyl methacrylate) (PDMA), which bears an azido group at the diblock junction (PEG-N 3(-PDMA)) was first prepared by atom transfer radical polymerization. Then, an alkynyl-terminated narrow distributed polytetrahydrofuran (PTHF-Alk) was synthesized as another building block via cationic ring opening polymerization. The well-defined H-shaped terpolymer was afforded by clicking PEG-N 3(-PDMA) onto both chain-ends of PTHF-Alk. This H-shaped terpolymer can self-assemble into micelles with different sizes and morphologies at various solution pH values. The micellar size also exhibits temperature-dependence at pH 7.4 and 9.2. The variation of size and morphology of the micelles with the solution pH and temperature is ascribed to the pH- and thermo-responsive properties of the PDMA block.

AB - We describe the synthesis and self-assembly of a well-defined H-shaped terpolymer in this paper. A block copolymer of poly(ethylene glycol) (PEG) and poly(N,N-dimethylaminoethyl methacrylate) (PDMA), which bears an azido group at the diblock junction (PEG-N 3(-PDMA)) was first prepared by atom transfer radical polymerization. Then, an alkynyl-terminated narrow distributed polytetrahydrofuran (PTHF-Alk) was synthesized as another building block via cationic ring opening polymerization. The well-defined H-shaped terpolymer was afforded by clicking PEG-N 3(-PDMA) onto both chain-ends of PTHF-Alk. This H-shaped terpolymer can self-assemble into micelles with different sizes and morphologies at various solution pH values. The micellar size also exhibits temperature-dependence at pH 7.4 and 9.2. The variation of size and morphology of the micelles with the solution pH and temperature is ascribed to the pH- and thermo-responsive properties of the PDMA block.

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U2 - 10.1039/c2py20586f

DO - 10.1039/c2py20586f

M3 - 文章

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SN - 1759-9954

VL - 3

SP - 3330

EP - 3339

JO - Polymer Chemistry

JF - Polymer Chemistry

IS - 12

ER -

Synthesis and stimulus-responsive micellization of a well-defined H-shaped terpolymer

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