Synthesis and in vitro antitumor activity of some tetraphenylantimony derivatives of exo-7-oxa-bicyclo[2,2,1]heptane(ene)-3-arylamide-2-acid

Jin Shan Li; Ma Yong-Qiang; Jing Rong Cui; Rui Qing Wang

doi:10.1002/aoc.200

Synthesis and in vitro antitumor activity of some tetraphenylantimony derivatives of exo-7-oxa-bicyclo[2,2,1]heptane(ene)-3-arylamide-2-acid

Jin Shan Li
, Ma Yong-Qiang
, Jing Rong Cui
, Rui Qing Wang

Nankai University
Peking University

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

A series of novel tetraphenylantimony derivatives of exo-7-oxa-bicyclo[2,2,1] heptane (ene)-3 -arylamide-2-acid of the general formula Ph₄SbO₂CCHCHCH₂CH₂CH(O)CHCONHAr (Ar = Ph,4-ClC₆H₄, 4-BrC₆H₄, 3-BrC₆H₄, 4-F-3-ClC₆H₃ and 4-MeC₆H₄) have been synthesized and characterized by elemental analysis, IR, ¹H NMR and mass spectra. The crystal structure of Ph₄SbO₂CCHCHCH₂CH₂ CH(O)CHCONHC₆H₄CH₃·CHCl₃ was determined by X-ray diffraction. Five human neoplastic cell lines (HL-60, KB, Bel-7402, BGC-823 and HCT-8) were used to screen these compounds. The results indicate that these compounds at 10 μM show certain in vitro antitumor activities.

Original language	English
Pages (from-to)	639-645
Number of pages	7
Journal	Applied Organometallic Chemistry
Volume	15
Issue number	7
DOIs	https://doi.org/10.1002/aoc.200
State	Published - 2001
Externally published	Yes

Keywords

Antimony
Antitumor activity
Crystal structure

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@article{2b10efa808bd424fa59059f26f3eb80a,

title = "Synthesis and in vitro antitumor activity of some tetraphenylantimony derivatives of exo-7-oxa-bicyclo[2,2,1]heptane(ene)-3-arylamide-2-acid",

abstract = "A series of novel tetraphenylantimony derivatives of exo-7-oxa-bicyclo[2,2,1] heptane (ene)-3 -arylamide-2-acid of the general formula Ph4SbO2CCHCHCH2CH2CH(O)CHCONHAr (Ar = Ph,4-ClC6H4, 4-BrC6H4, 3-BrC6H4, 4-F-3-ClC6H3 and 4-MeC6H4) have been synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectra. The crystal structure of Ph4SbO2CCHCHCH2CH2 CH(O)CHCONHC6H4CH3·CHCl3 was determined by X-ray diffraction. Five human neoplastic cell lines (HL-60, KB, Bel-7402, BGC-823 and HCT-8) were used to screen these compounds. The results indicate that these compounds at 10 μM show certain in vitro antitumor activities.",

keywords = "Antimony, Antitumor activity, Crystal structure",

author = "Li, \{Jin Shan\} and Ma Yong-Qiang and Cui, \{Jing Rong\} and Wang, \{Rui Qing\}",

year = "2001",

doi = "10.1002/aoc.200",

language = "英语",

volume = "15",

pages = "639--645",

journal = "Applied Organometallic Chemistry",

issn = "0268-2605",

publisher = "John Wiley and Sons Ltd",

number = "7",

}

TY - JOUR

T1 - Synthesis and in vitro antitumor activity of some tetraphenylantimony derivatives of exo-7-oxa-bicyclo[2,2,1]heptane(ene)-3-arylamide-2-acid

AU - Li, Jin Shan

AU - Yong-Qiang, Ma

AU - Cui, Jing Rong

AU - Wang, Rui Qing

PY - 2001

Y1 - 2001

N2 - A series of novel tetraphenylantimony derivatives of exo-7-oxa-bicyclo[2,2,1] heptane (ene)-3 -arylamide-2-acid of the general formula Ph4SbO2CCHCHCH2CH2CH(O)CHCONHAr (Ar = Ph,4-ClC6H4, 4-BrC6H4, 3-BrC6H4, 4-F-3-ClC6H3 and 4-MeC6H4) have been synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectra. The crystal structure of Ph4SbO2CCHCHCH2CH2 CH(O)CHCONHC6H4CH3·CHCl3 was determined by X-ray diffraction. Five human neoplastic cell lines (HL-60, KB, Bel-7402, BGC-823 and HCT-8) were used to screen these compounds. The results indicate that these compounds at 10 μM show certain in vitro antitumor activities.

AB - A series of novel tetraphenylantimony derivatives of exo-7-oxa-bicyclo[2,2,1] heptane (ene)-3 -arylamide-2-acid of the general formula Ph4SbO2CCHCHCH2CH2CH(O)CHCONHAr (Ar = Ph,4-ClC6H4, 4-BrC6H4, 3-BrC6H4, 4-F-3-ClC6H3 and 4-MeC6H4) have been synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectra. The crystal structure of Ph4SbO2CCHCHCH2CH2 CH(O)CHCONHC6H4CH3·CHCl3 was determined by X-ray diffraction. Five human neoplastic cell lines (HL-60, KB, Bel-7402, BGC-823 and HCT-8) were used to screen these compounds. The results indicate that these compounds at 10 μM show certain in vitro antitumor activities.

KW - Antimony

KW - Antitumor activity

KW - Crystal structure

UR - https://www.scopus.com/pages/publications/0034950704

U2 - 10.1002/aoc.200

DO - 10.1002/aoc.200

M3 - 文章

AN - SCOPUS:0034950704

SN - 0268-2605

VL - 15

SP - 639

EP - 645

JO - Applied Organometallic Chemistry

JF - Applied Organometallic Chemistry

IS - 7

ER -

Synthesis and in vitro antitumor activity of some tetraphenylantimony derivatives of exo-7-oxa-bicyclo[2,2,1]heptane(ene)-3-arylamide-2-acid

Abstract

Keywords

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