TY - JOUR
T1 - Surface modification of titanium substrates for enhanced osteogenetic and antibacterial properties
AU - Liu, Peng
AU - Hao, Yansha
AU - Zhao, Yongchun
AU - Yuan, Zhang
AU - Ding, Yao
AU - Cai, Kaiyong
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - The insufficient osseointegration and bacterial infection of titanium and its alloys remain the key challenges in their clinic applications, which may result in failure implantation. To improve osteogenetic and antibacterial properties, TiO2 nanotube arrays were fabricated on titanium substrates for loading of antibacterial drug. Then, TiO2 nanotube arrays were covered with chitosan/sodium alginate multilayer films. The successful construction of this system was verified via scanning electron microscopy and contact angle measurement. The cytocompatibility evaluation in vitro, including cytoskeleton observation, cell viability measurement, and alkaline phosphatase activity assay, confirmed that the present system was capable of accelerating the growth of osteoblasts. In addition, bacterial adhesion and viability assay verified that treated Ti substrates were capable of reducing the adhesion of bacteria. This study may provide an alternative to develop titanium-based implants for enhanced bone osseointegration and reduced bacterial infection.
AB - The insufficient osseointegration and bacterial infection of titanium and its alloys remain the key challenges in their clinic applications, which may result in failure implantation. To improve osteogenetic and antibacterial properties, TiO2 nanotube arrays were fabricated on titanium substrates for loading of antibacterial drug. Then, TiO2 nanotube arrays were covered with chitosan/sodium alginate multilayer films. The successful construction of this system was verified via scanning electron microscopy and contact angle measurement. The cytocompatibility evaluation in vitro, including cytoskeleton observation, cell viability measurement, and alkaline phosphatase activity assay, confirmed that the present system was capable of accelerating the growth of osteoblasts. In addition, bacterial adhesion and viability assay verified that treated Ti substrates were capable of reducing the adhesion of bacteria. This study may provide an alternative to develop titanium-based implants for enhanced bone osseointegration and reduced bacterial infection.
KW - Antibacterial property
KW - Layer-by-layer self-assembly
KW - Nanotopography
KW - Osteoblasts
KW - Surface modification
UR - http://www.scopus.com/inward/record.url?scp=85029387904&partnerID=8YFLogxK
U2 - 10.1016/j.colsurfb.2017.08.044
DO - 10.1016/j.colsurfb.2017.08.044
M3 - 文章
C2 - 28918187
AN - SCOPUS:85029387904
SN - 0927-7765
VL - 160
SP - 110
EP - 116
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
ER -