Structural Engineering of Furazanopyrazine Scaffolds with Flexible Biogenic Amines and Nitramine Moieties for Fused Energetic Melt-Castable Materials

Wei Du; Weihua Zhu; Jinshan Li; Qing Ma

doi:10.1021/acs.orglett.6c01619

Structural Engineering of Furazanopyrazine Scaffolds with Flexible Biogenic Amines and Nitramine Moieties for Fused Energetic Melt-Castable Materials

Wei Du
, Weihua Zhu
, Jinshan Li
, Qing Ma

China Academy of Engineering Physics
Nanjing University of Science and Technology

Research output: Contribution to journal › Letter › peer-review

Abstract

Furazanopyrazine-based energetic compounds were developed through a substitution–nitration strategy combining flexible biogenic amine side chains with nitramine modification. Structural and thermal analyses revealed that side-chain flexibility effectively tunes crystal packing and phase behavior. Among compounds I–VII·H₂O, compound II exhibited the most favorable melt-cast characteristics, with a melting point of 89 °C, competitive detonation performance, and acceptable sensitivities. These results offer a useful design strategy for fused-ring melt-cast energetic materials.

Original language	English
Pages (from-to)	7004-7008
Number of pages	5
Journal	Organic Letters
Volume	28
Issue number	22
DOIs	https://doi.org/10.1021/acs.orglett.6c01619
State	Published - 5 Jun 2026
Externally published	Yes

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10.1021/acs.orglett.6c01619

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title = "Structural Engineering of Furazanopyrazine Scaffolds with Flexible Biogenic Amines and Nitramine Moieties for Fused Energetic Melt-Castable Materials",

abstract = "Furazanopyrazine-based energetic compounds were developed through a substitution–nitration strategy combining flexible biogenic amine side chains with nitramine modification. Structural and thermal analyses revealed that side-chain flexibility effectively tunes crystal packing and phase behavior. Among compounds I–VII·H2O, compound II exhibited the most favorable melt-cast characteristics, with a melting point of 89 °C, competitive detonation performance, and acceptable sensitivities. These results offer a useful design strategy for fused-ring melt-cast energetic materials.",

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T1 - Structural Engineering of Furazanopyrazine Scaffolds with Flexible Biogenic Amines and Nitramine Moieties for Fused Energetic Melt-Castable Materials

AU - Du, Wei

AU - Zhu, Weihua

AU - Li, Jinshan

AU - Ma, Qing

PY - 2026/6/5

Y1 - 2026/6/5

N2 - Furazanopyrazine-based energetic compounds were developed through a substitution–nitration strategy combining flexible biogenic amine side chains with nitramine modification. Structural and thermal analyses revealed that side-chain flexibility effectively tunes crystal packing and phase behavior. Among compounds I–VII·H2O, compound II exhibited the most favorable melt-cast characteristics, with a melting point of 89 °C, competitive detonation performance, and acceptable sensitivities. These results offer a useful design strategy for fused-ring melt-cast energetic materials.

AB - Furazanopyrazine-based energetic compounds were developed through a substitution–nitration strategy combining flexible biogenic amine side chains with nitramine modification. Structural and thermal analyses revealed that side-chain flexibility effectively tunes crystal packing and phase behavior. Among compounds I–VII·H2O, compound II exhibited the most favorable melt-cast characteristics, with a melting point of 89 °C, competitive detonation performance, and acceptable sensitivities. These results offer a useful design strategy for fused-ring melt-cast energetic materials.

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DO - 10.1021/acs.orglett.6c01619

M3 - 快报

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JF - Organic Letters

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ER -

Structural Engineering of Furazanopyrazine Scaffolds with Flexible Biogenic Amines and Nitramine Moieties for Fused Energetic Melt-Castable Materials

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