Abstract
We investigate the phenomenon that stochastic fluctuation induced the competition between tumor extinction and recurrence in the model of tumor growth derived from the catalytic Michaelis-Menten reaction. We analyze the probability transitions between the extinction state and the state of the stable tumor by the Mean First Extinction Time (MFET) and Mean First Return Time (MFRT). It is found that the positional fluctuations hinder the transition, but the environmental fluctuations, to a certain level, facilitate the tumor extinction. The observed behavior could be used as prior information for the treatment of cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 1771-1776 |
| Number of pages | 6 |
| Journal | Physics Letters, Section A: General, Atomic and Solid State Physics |
| Volume | 376 |
| Issue number | 22 |
| DOIs | |
| State | Published - 30 Apr 2012 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Model of tumor growth
- Stochastic fluctuation
- Tumor extinction
- Tumor recurrence
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