Size-Stable Supramolecular Hyperbranched Polymer Vesicles for Redox-Triggered Double-Drug Release

Supramolecular polymer vesicles (SPVs) with stimuli-responsive features are promising multifunctional nanocarriers; however, improving the stability and developing multiple-drug-loaded SPVs remain key issues in this field. In this work, cross-linked supramolecular hyperbranched polymer vesicles (SHPVs) with redox-responsiveness are first constructed based on an AB₂-type macromonomer-synthesized SHP. The obtained cross-linked SHPVs exhibit much better size stability than those of non-cross-linked branched self-assemblies, and higher double-drug-loading capacity compared with linear supramolecular polymer self-assemblies. Particularly, these cross-linked SHPVs exhibit a redox-triggered, controlled double-drug release behavior upon the addition of H₂O₂.