Single nanoparticles as versatile phototheranostics for tri-modal imaging-guided photothermal therapy

Xiaomei Lu; Jiaqi Chen; Jie Li; Bing Xia; Jingzeng Xu; Qi Wang; Chen Xie; Quli Fan; Wei Huang

doi:10.1039/c9bm00997c

Single nanoparticles as versatile phototheranostics for tri-modal imaging-guided photothermal therapy

Xiaomei Lu
, Jiaqi Chen
, Jie Li
, Bing Xia
, Jingzeng Xu
, Qi Wang
, Chen Xie
, Quli Fan
, Wei Huang

Nanjing Tech University
Nanjing University of Posts and Telecommunications
Hunan University

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Development of versatile phototheranostics is highly desirable for cancer theranostics. Herein, a novel organic conjugated polymer (named DPP-TT) with excellent optical properties was designed and prepared. Based on single-component DPP-TT, single DPP-TT NPs as versatile phototheranostics were developed by a simple nanoprecipitation method. The obtained NPs exhibited good water solubility, excellent biocompatibility, outstanding photostability, strong NIR-I light absorption, and appropriate NIR-II fluorescence emission. Importantly, such NPs presented high photothermal conversion efficiency. From the investigations performed in vitro and in vivo, it was observed that DPP-TT NPs show remarkable performance for cancer theranostics, benefiting from single 808 nm laser-induced tri-modal (NIR-II fluorescence/photoacoustic/thermal) imaging-guided photothermal therapy.

Original language	English
Pages (from-to)	3609-3613
Number of pages	5
Journal	Biomaterials Science
Volume	7
Issue number	9
DOIs	https://doi.org/10.1039/c9bm00997c
State	Published - Sep 2019
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1039/c9bm00997c

Cite this

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title = "Single nanoparticles as versatile phototheranostics for tri-modal imaging-guided photothermal therapy",

abstract = "Development of versatile phototheranostics is highly desirable for cancer theranostics. Herein, a novel organic conjugated polymer (named DPP-TT) with excellent optical properties was designed and prepared. Based on single-component DPP-TT, single DPP-TT NPs as versatile phototheranostics were developed by a simple nanoprecipitation method. The obtained NPs exhibited good water solubility, excellent biocompatibility, outstanding photostability, strong NIR-I light absorption, and appropriate NIR-II fluorescence emission. Importantly, such NPs presented high photothermal conversion efficiency. From the investigations performed in vitro and in vivo, it was observed that DPP-TT NPs show remarkable performance for cancer theranostics, benefiting from single 808 nm laser-induced tri-modal (NIR-II fluorescence/photoacoustic/thermal) imaging-guided photothermal therapy.",

author = "Xiaomei Lu and Jiaqi Chen and Jie Li and Bing Xia and Jingzeng Xu and Qi Wang and Chen Xie and Quli Fan and Wei Huang",

note = "Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

year = "2019",

month = sep,

doi = "10.1039/c9bm00997c",

language = "英语",

volume = "7",

pages = "3609--3613",

journal = "Biomaterials Science",

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TY - JOUR

T1 - Single nanoparticles as versatile phototheranostics for tri-modal imaging-guided photothermal therapy

AU - Lu, Xiaomei

AU - Chen, Jiaqi

AU - Li, Jie

AU - Xia, Bing

AU - Xu, Jingzeng

AU - Wang, Qi

AU - Xie, Chen

AU - Fan, Quli

AU - Huang, Wei

PY - 2019/9

Y1 - 2019/9

N2 - Development of versatile phototheranostics is highly desirable for cancer theranostics. Herein, a novel organic conjugated polymer (named DPP-TT) with excellent optical properties was designed and prepared. Based on single-component DPP-TT, single DPP-TT NPs as versatile phototheranostics were developed by a simple nanoprecipitation method. The obtained NPs exhibited good water solubility, excellent biocompatibility, outstanding photostability, strong NIR-I light absorption, and appropriate NIR-II fluorescence emission. Importantly, such NPs presented high photothermal conversion efficiency. From the investigations performed in vitro and in vivo, it was observed that DPP-TT NPs show remarkable performance for cancer theranostics, benefiting from single 808 nm laser-induced tri-modal (NIR-II fluorescence/photoacoustic/thermal) imaging-guided photothermal therapy.

AB - Development of versatile phototheranostics is highly desirable for cancer theranostics. Herein, a novel organic conjugated polymer (named DPP-TT) with excellent optical properties was designed and prepared. Based on single-component DPP-TT, single DPP-TT NPs as versatile phototheranostics were developed by a simple nanoprecipitation method. The obtained NPs exhibited good water solubility, excellent biocompatibility, outstanding photostability, strong NIR-I light absorption, and appropriate NIR-II fluorescence emission. Importantly, such NPs presented high photothermal conversion efficiency. From the investigations performed in vitro and in vivo, it was observed that DPP-TT NPs show remarkable performance for cancer theranostics, benefiting from single 808 nm laser-induced tri-modal (NIR-II fluorescence/photoacoustic/thermal) imaging-guided photothermal therapy.

UR - https://www.scopus.com/pages/publications/85071361217

U2 - 10.1039/c9bm00997c

DO - 10.1039/c9bm00997c

M3 - 文章

C2 - 31361290

AN - SCOPUS:85071361217

SN - 2047-4830

VL - 7

SP - 3609

EP - 3613

JO - Biomaterials Science

JF - Biomaterials Science

IS - 9

ER -

Single nanoparticles as versatile phototheranostics for tri-modal imaging-guided photothermal therapy

Abstract

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