Simulated weightlessness alters biological characteristics of human breast cancer cell line MCF-7

Airong R. Qian; Wei Zhang; Li Xie; Yuanyuan Weng; Pengfei Yang; Zhe Wang; Lifang Hu; Huiyun Xu; Zongcheng Tian; Peng Shang

doi:10.1016/j.actaastro.2008.01.024

Simulated weightlessness alters biological characteristics of human breast cancer cell line MCF-7

Airong R. Qian
, Wei Zhang
, Li Xie
, Yuanyuan Weng
, Pengfei Yang
, Zhe Wang
, Lifang Hu
, Huiyun Xu
, Zongcheng Tian
, Peng Shang

School of life sciences

Northwestern Polytechnical University Xian

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The aim of this study is to investigate the effects of the clinostat-simulated microgravity on MCF-7 cells (a breast cancer cell line) biological characteristics. MCF-7 cells were incubated for 24 h in an incubator and then rotated in a clinostat as a model of simulated microgravity for 24, 48 and 72 h, respectively. The effects of the clinostat-simulated microgravity on MCF-7 cells proliferation, invasion, migration, gelatinase production, adhesion, cell cycle, apoptosis and vinculin expression were detected. The results showed that the clinostat-simulated microgravity affected breast cancer cell invasion, migration, adhesion, cell cycle, cell apoptosis and vinculin expression. These results may explore a new field of vision to study tumor metastasis in future.

Original language	English
Pages (from-to)	947-958
Number of pages	12
Journal	Acta Astronautica
Volume	63
Issue number	7-10
DOIs	https://doi.org/10.1016/j.actaastro.2008.01.024
State	Published - Oct 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adhesion
Apoptosis
Breast cancer
Cell cycle
Invasion
Simulated microgravity

Access to Document

10.1016/j.actaastro.2008.01.024

Cite this

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title = "Simulated weightlessness alters biological characteristics of human breast cancer cell line MCF-7",

abstract = "The aim of this study is to investigate the effects of the clinostat-simulated microgravity on MCF-7 cells (a breast cancer cell line) biological characteristics. MCF-7 cells were incubated for 24 h in an incubator and then rotated in a clinostat as a model of simulated microgravity for 24, 48 and 72 h, respectively. The effects of the clinostat-simulated microgravity on MCF-7 cells proliferation, invasion, migration, gelatinase production, adhesion, cell cycle, apoptosis and vinculin expression were detected. The results showed that the clinostat-simulated microgravity affected breast cancer cell invasion, migration, adhesion, cell cycle, cell apoptosis and vinculin expression. These results may explore a new field of vision to study tumor metastasis in future.",

keywords = "Adhesion, Apoptosis, Breast cancer, Cell cycle, Invasion, Simulated microgravity",

author = "Qian, \{Airong R.\} and Wei Zhang and Li Xie and Yuanyuan Weng and Pengfei Yang and Zhe Wang and Lifang Hu and Huiyun Xu and Zongcheng Tian and Peng Shang",

year = "2008",

month = oct,

doi = "10.1016/j.actaastro.2008.01.024",

language = "英语",

volume = "63",

pages = "947--958",

journal = "Acta Astronautica",

issn = "0094-5765",

publisher = "Elsevier Ltd",

number = "7-10",

}

TY - JOUR

T1 - Simulated weightlessness alters biological characteristics of human breast cancer cell line MCF-7

AU - Qian, Airong R.

AU - Zhang, Wei

AU - Xie, Li

AU - Weng, Yuanyuan

AU - Yang, Pengfei

AU - Wang, Zhe

AU - Hu, Lifang

AU - Xu, Huiyun

AU - Tian, Zongcheng

AU - Shang, Peng

PY - 2008/10

Y1 - 2008/10

N2 - The aim of this study is to investigate the effects of the clinostat-simulated microgravity on MCF-7 cells (a breast cancer cell line) biological characteristics. MCF-7 cells were incubated for 24 h in an incubator and then rotated in a clinostat as a model of simulated microgravity for 24, 48 and 72 h, respectively. The effects of the clinostat-simulated microgravity on MCF-7 cells proliferation, invasion, migration, gelatinase production, adhesion, cell cycle, apoptosis and vinculin expression were detected. The results showed that the clinostat-simulated microgravity affected breast cancer cell invasion, migration, adhesion, cell cycle, cell apoptosis and vinculin expression. These results may explore a new field of vision to study tumor metastasis in future.

AB - The aim of this study is to investigate the effects of the clinostat-simulated microgravity on MCF-7 cells (a breast cancer cell line) biological characteristics. MCF-7 cells were incubated for 24 h in an incubator and then rotated in a clinostat as a model of simulated microgravity for 24, 48 and 72 h, respectively. The effects of the clinostat-simulated microgravity on MCF-7 cells proliferation, invasion, migration, gelatinase production, adhesion, cell cycle, apoptosis and vinculin expression were detected. The results showed that the clinostat-simulated microgravity affected breast cancer cell invasion, migration, adhesion, cell cycle, cell apoptosis and vinculin expression. These results may explore a new field of vision to study tumor metastasis in future.

KW - Adhesion

KW - Apoptosis

KW - Breast cancer

KW - Cell cycle

KW - Invasion

KW - Simulated microgravity

UR - https://www.scopus.com/pages/publications/48549100952

U2 - 10.1016/j.actaastro.2008.01.024

DO - 10.1016/j.actaastro.2008.01.024

M3 - 文章

AN - SCOPUS:48549100952

SN - 0094-5765

VL - 63

SP - 947

EP - 958

JO - Acta Astronautica

JF - Acta Astronautica

IS - 7-10

ER -

Simulated weightlessness alters biological characteristics of human breast cancer cell line MCF-7

Abstract

UN SDGs

Keywords

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