Simulated weightlessness alters biological characteristics of human breast cancer cell line MCF-7

Airong R. Qian; Wei Zhang; Li Xie; Yuanyuan Weng; Pengfei Yang; Zhe Wang; Lifang Hu; Huiyun Xu; Zongcheng Tian; Peng Shang

doi:10.1016/j.actaastro.2008.01.024

Simulated weightlessness alters biological characteristics of human breast cancer cell line MCF-7

Airong R. Qian, Wei Zhang, Li Xie, Yuanyuan Weng, Pengfei Yang, Zhe Wang, Lifang Hu, Huiyun Xu, Zongcheng Tian, Peng Shang

School of life sciences

Northwestern Polytechnical University Xian

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The aim of this study is to investigate the effects of the clinostat-simulated microgravity on MCF-7 cells (a breast cancer cell line) biological characteristics. MCF-7 cells were incubated for 24 h in an incubator and then rotated in a clinostat as a model of simulated microgravity for 24, 48 and 72 h, respectively. The effects of the clinostat-simulated microgravity on MCF-7 cells proliferation, invasion, migration, gelatinase production, adhesion, cell cycle, apoptosis and vinculin expression were detected. The results showed that the clinostat-simulated microgravity affected breast cancer cell invasion, migration, adhesion, cell cycle, cell apoptosis and vinculin expression. These results may explore a new field of vision to study tumor metastasis in future.

Original language	English
Pages (from-to)	947-958
Number of pages	12
Journal	Acta Astronautica
Volume	63
Issue number	7-10
DOIs	https://doi.org/10.1016/j.actaastro.2008.01.024
State	Published - Oct 2008

Keywords

Adhesion
Apoptosis
Breast cancer
Cell cycle
Invasion
Simulated microgravity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.actaastro.2008.01.024

Cite this

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title = "Simulated weightlessness alters biological characteristics of human breast cancer cell line MCF-7",

abstract = "The aim of this study is to investigate the effects of the clinostat-simulated microgravity on MCF-7 cells (a breast cancer cell line) biological characteristics. MCF-7 cells were incubated for 24 h in an incubator and then rotated in a clinostat as a model of simulated microgravity for 24, 48 and 72 h, respectively. The effects of the clinostat-simulated microgravity on MCF-7 cells proliferation, invasion, migration, gelatinase production, adhesion, cell cycle, apoptosis and vinculin expression were detected. The results showed that the clinostat-simulated microgravity affected breast cancer cell invasion, migration, adhesion, cell cycle, cell apoptosis and vinculin expression. These results may explore a new field of vision to study tumor metastasis in future.",

keywords = "Adhesion, Apoptosis, Breast cancer, Cell cycle, Invasion, Simulated microgravity",

author = "Qian, {Airong R.} and Wei Zhang and Li Xie and Yuanyuan Weng and Pengfei Yang and Zhe Wang and Lifang Hu and Huiyun Xu and Zongcheng Tian and Peng Shang",

year = "2008",

month = oct,

doi = "10.1016/j.actaastro.2008.01.024",

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volume = "63",

pages = "947--958",

journal = "Acta Astronautica",

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number = "7-10",

}

TY - JOUR

T1 - Simulated weightlessness alters biological characteristics of human breast cancer cell line MCF-7

AU - Qian, Airong R.

AU - Zhang, Wei

AU - Xie, Li

AU - Weng, Yuanyuan

AU - Yang, Pengfei

AU - Wang, Zhe

AU - Hu, Lifang

AU - Xu, Huiyun

AU - Tian, Zongcheng

AU - Shang, Peng

PY - 2008/10

Y1 - 2008/10

N2 - The aim of this study is to investigate the effects of the clinostat-simulated microgravity on MCF-7 cells (a breast cancer cell line) biological characteristics. MCF-7 cells were incubated for 24 h in an incubator and then rotated in a clinostat as a model of simulated microgravity for 24, 48 and 72 h, respectively. The effects of the clinostat-simulated microgravity on MCF-7 cells proliferation, invasion, migration, gelatinase production, adhesion, cell cycle, apoptosis and vinculin expression were detected. The results showed that the clinostat-simulated microgravity affected breast cancer cell invasion, migration, adhesion, cell cycle, cell apoptosis and vinculin expression. These results may explore a new field of vision to study tumor metastasis in future.

AB - The aim of this study is to investigate the effects of the clinostat-simulated microgravity on MCF-7 cells (a breast cancer cell line) biological characteristics. MCF-7 cells were incubated for 24 h in an incubator and then rotated in a clinostat as a model of simulated microgravity for 24, 48 and 72 h, respectively. The effects of the clinostat-simulated microgravity on MCF-7 cells proliferation, invasion, migration, gelatinase production, adhesion, cell cycle, apoptosis and vinculin expression were detected. The results showed that the clinostat-simulated microgravity affected breast cancer cell invasion, migration, adhesion, cell cycle, cell apoptosis and vinculin expression. These results may explore a new field of vision to study tumor metastasis in future.

KW - Adhesion

KW - Apoptosis

KW - Breast cancer

KW - Cell cycle

KW - Invasion

KW - Simulated microgravity

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U2 - 10.1016/j.actaastro.2008.01.024

DO - 10.1016/j.actaastro.2008.01.024

M3 - 文章

AN - SCOPUS:48549100952

SN - 0094-5765

VL - 63

SP - 947

EP - 958

JO - Acta Astronautica

JF - Acta Astronautica

IS - 7-10

ER -

Simulated weightlessness alters biological characteristics of human breast cancer cell line MCF-7

Abstract

Keywords

UN SDGs

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