RNA Therapy in Bone Diseases

Bones are constantly modeling and remodeling in a stable internal environment. When the homeostasis is damaged with age growth and pathological conditions, bone diseases, such as osteoarthritis (OA), osteoporosis (OP), bone tumor, and so on, will occur. Bone diseases represented severe public health threats with limited therapy approach. However, traditional medicine treatment for these bone disorders had certain limitations. Increasing evidences revealed that diverse ncRNAs play critical roles in occurrence of the bone disorders. In the recently decades, more and more studies prompted that targeting ncRNAs might become an attractive and new therapeutic strategy for bone related diseases. This chapter will highlight the recent advance in the development of ncRNA in bone disease and discuss the possibilities for RNA therapy in bone disease treatment.