Rapid Shape Recovery Sponge with Reinforced Skeletons Prepared by Centrifugation-Assisted Mechanochemical Crosslinking Strategy for Noncompressible Hemostasis

Developing hemostatic sponges with excellent liquid absorption capacity and rapid shape recovery is urgently required to achieve immediate hemostasis in noncompressible wounds. However, balancing the high porosity and rapid shape recovery of hemostatic sponges prepared using traditional methods is difficult. A high-porosity structure leads to insufficient skeleton strength, significantly delaying the recovery speed. In this study, a simple yet versatile centrifugation-assisted mechanochemical crosslinking (CAMC) strategy is employed to fabricate sponges with reinforced skeletons while maintaining a high porosity (94%). The resultant mechanochemically crosslinked sericin sponge (mcSS) achieved water-triggered shape recovery (1.11 s) and absorbed 26 times its original weight in water. Moreover, mcSS demonstrated exceptional hemostatic efficacy in multiple rat hemorrhage models by co-activating both endogenous and exogenous coagulation pathways. The subcutaneous implantation of mcSS promotes cell migration, angiogenesis, and host tissue infiltration This paper proposes a simple and efficient centrifugal mechanochemical crosslinking strategy for preparing hemostatic sponges with excellent liquid absorption capacity and rapid shape memory recovery, thereby providing a new solution for rapid hemostasis in noncompressible wounds.