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Preparation of collagen/hydroxyapatite composite coating on porous Titanium substrate and its cellular response

  • Northwestern Polytechnical University Xian

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

In this article, the layered deposition method is adopted to prepare the collagen/hydroxyapatite(COL/HA) composite coating. The morphology and elements of the COL/HA composite coating are observed using a scanning electron microscope(SEM)with an energy dispersive spectrometer(EDS), the optical density(O.D.) values are obtained by MTT assay to assess the cellular viabilityof composite coating. The experimental results showed that the addition of collagen not only improve the bonding strength of composite coating and porous titanium substrate, but also combine the osteoconduction of inorganic coating HA and the osteoinduction of organic coating COL, effectively enhance the cellular adhesion, proliferation and differentiation. The cellular viability cultured in COL/HA composite coating is much higher than the pure HA modified coating.

Original languageEnglish
Title of host publicationAdvanced Functional Materials
EditorsYafang Han, Zhongwei Gu, Qiang Fu
PublisherTrans Tech Publications Ltd
Pages429-433
Number of pages5
ISBN (Electronic)9783038353942
DOIs
StatePublished - 2015
EventChinese Materials Congress, CMC 2014 - Chengdu, China
Duration: 4 Jul 20147 Jul 2014

Publication series

NameMaterials Science Forum
Volume815
ISSN (Print)0255-5476
ISSN (Electronic)1662-9752

Conference

ConferenceChinese Materials Congress, CMC 2014
Country/TerritoryChina
CityChengdu
Period4/07/147/07/14

Keywords

  • Cellular response
  • COL/HA composite coating
  • Porous titanium

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