Porphyrin-cored dendrimers consisting of novel siloxane-poly (amido amine) dendron-like arms: Synthesis, characterization, and photophysical properties

Xiao Hui Dai; Wei He Yang; Wen Li Yan; Jia Ming Hu; Yi Rong Dai; Jian Ming Pan; Yong Sheng Yan

doi:10.1016/j.colsurfa.2017.01.064

Porphyrin-cored dendrimers consisting of novel siloxane-poly (amido amine) dendron-like arms: Synthesis, characterization, and photophysical properties

Xiao Hui Dai
, Wei He Yang
, Wen Li Yan
, Jia Ming Hu
, Yi Rong Dai
, Jian Ming Pan
, Yong Sheng Yan

Jiangsu University
Hunan Agricultural University

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Different generations of porphyrin-cored dendrimers consisting of novel siloxane- poly(amido amine) dendron-like arms have been synthesized via copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of azide-modified 5,10,15,20-tetrakis(4-hydroxyphenyl)-porphyrin with different generations of propargyl focal point novel siloxane-poly(amido amine) typed dendron (Si-PAMAM). The used different generations of Si-PAMAM were obtained by the “arm-first” strategy based on the Michael addition reaction and Amidation reaction, orderly. The structure of porphyrin dendrimers is established by ¹H NMR, ¹³C NMR, MALDI-TOF-MS and FT-IR analysis. PP-Si-PAMAM-Dm (m = 1, 2, and 3), not only gave strong fluorescence emission and the intensity increased significantly as the generation growing, but also showed a remarkable pH-responsive in fluorescence emission. These interesting properties indicate that synthesized porphyrin dendrimers may be able to act as pH-responsive probes suitable for biomedical imaging, diagnosis and treatment.

Original language	English
Pages (from-to)	222-230
Number of pages	9
Journal	Colloids and Surfaces A: Physicochemical and Engineering Aspects
Volume	520
DOIs	https://doi.org/10.1016/j.colsurfa.2017.01.064
State	Published - 5 May 2017
Externally published	Yes

Keywords

Click chemistry
Fluorescence
Porphyrin dendrimers
Si-PAMAM
pH-response

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10.1016/j.colsurfa.2017.01.064

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Dai, X. H., Yang, W. H., Yan, W. L., Hu, J. M., Dai, Y. R., Pan, J. M., & Yan, Y. S. (2017). Porphyrin-cored dendrimers consisting of novel siloxane-poly (amido amine) dendron-like arms: Synthesis, characterization, and photophysical properties. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 520, 222-230. https://doi.org/10.1016/j.colsurfa.2017.01.064

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title = "Porphyrin-cored dendrimers consisting of novel siloxane-poly (amido amine) dendron-like arms: Synthesis, characterization, and photophysical properties",

abstract = "Different generations of porphyrin-cored dendrimers consisting of novel siloxane- poly(amido amine) dendron-like arms have been synthesized via copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of azide-modified 5,10,15,20-tetrakis(4-hydroxyphenyl)-porphyrin with different generations of propargyl focal point novel siloxane-poly(amido amine) typed dendron (Si-PAMAM). The used different generations of Si-PAMAM were obtained by the “arm-first” strategy based on the Michael addition reaction and Amidation reaction, orderly. The structure of porphyrin dendrimers is established by 1H NMR, 13C NMR, MALDI-TOF-MS and FT-IR analysis. PP-Si-PAMAM-Dm (m = 1, 2, and 3), not only gave strong fluorescence emission and the intensity increased significantly as the generation growing, but also showed a remarkable pH-responsive in fluorescence emission. These interesting properties indicate that synthesized porphyrin dendrimers may be able to act as pH-responsive probes suitable for biomedical imaging, diagnosis and treatment.",

keywords = "Click chemistry, Fluorescence, Porphyrin dendrimers, Si-PAMAM, pH-response",

author = "Dai, \{Xiao Hui\} and Yang, \{Wei He\} and Yan, \{Wen Li\} and Hu, \{Jia Ming\} and Dai, \{Yi Rong\} and Pan, \{Jian Ming\} and Yan, \{Yong Sheng\}",

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year = "2017",

month = may,

day = "5",

doi = "10.1016/j.colsurfa.2017.01.064",

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journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",

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Porphyrin-cored dendrimers consisting of novel siloxane-poly (amido amine) dendron-like arms: Synthesis, characterization, and photophysical properties. / Dai, Xiao Hui; Yang, Wei He; Yan, Wen Li et al.
In: Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 520, 05.05.2017, p. 222-230.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Porphyrin-cored dendrimers consisting of novel siloxane-poly (amido amine) dendron-like arms

T2 - Synthesis, characterization, and photophysical properties

AU - Dai, Xiao Hui

AU - Yang, Wei He

AU - Yan, Wen Li

AU - Hu, Jia Ming

AU - Dai, Yi Rong

AU - Pan, Jian Ming

AU - Yan, Yong Sheng

PY - 2017/5/5

Y1 - 2017/5/5

N2 - Different generations of porphyrin-cored dendrimers consisting of novel siloxane- poly(amido amine) dendron-like arms have been synthesized via copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of azide-modified 5,10,15,20-tetrakis(4-hydroxyphenyl)-porphyrin with different generations of propargyl focal point novel siloxane-poly(amido amine) typed dendron (Si-PAMAM). The used different generations of Si-PAMAM were obtained by the “arm-first” strategy based on the Michael addition reaction and Amidation reaction, orderly. The structure of porphyrin dendrimers is established by 1H NMR, 13C NMR, MALDI-TOF-MS and FT-IR analysis. PP-Si-PAMAM-Dm (m = 1, 2, and 3), not only gave strong fluorescence emission and the intensity increased significantly as the generation growing, but also showed a remarkable pH-responsive in fluorescence emission. These interesting properties indicate that synthesized porphyrin dendrimers may be able to act as pH-responsive probes suitable for biomedical imaging, diagnosis and treatment.

AB - Different generations of porphyrin-cored dendrimers consisting of novel siloxane- poly(amido amine) dendron-like arms have been synthesized via copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of azide-modified 5,10,15,20-tetrakis(4-hydroxyphenyl)-porphyrin with different generations of propargyl focal point novel siloxane-poly(amido amine) typed dendron (Si-PAMAM). The used different generations of Si-PAMAM were obtained by the “arm-first” strategy based on the Michael addition reaction and Amidation reaction, orderly. The structure of porphyrin dendrimers is established by 1H NMR, 13C NMR, MALDI-TOF-MS and FT-IR analysis. PP-Si-PAMAM-Dm (m = 1, 2, and 3), not only gave strong fluorescence emission and the intensity increased significantly as the generation growing, but also showed a remarkable pH-responsive in fluorescence emission. These interesting properties indicate that synthesized porphyrin dendrimers may be able to act as pH-responsive probes suitable for biomedical imaging, diagnosis and treatment.

KW - Click chemistry

KW - Fluorescence

KW - Porphyrin dendrimers

KW - Si-PAMAM

KW - pH-response

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U2 - 10.1016/j.colsurfa.2017.01.064

DO - 10.1016/j.colsurfa.2017.01.064

M3 - 文章

AN - SCOPUS:85012278994

SN - 0927-7757

VL - 520

SP - 222

EP - 230

JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects

JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects

ER -

Porphyrin-cored dendrimers consisting of novel siloxane-poly (amido amine) dendron-like arms: Synthesis, characterization, and photophysical properties

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Keywords

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