Photothermal-triggered release of singlet oxygen from an endoperoxide-containing polymeric carrier for killing cancer cells

Wen Lv; Huiting Xia; Kenneth Yin Zhang; Zejing Chen; Shujuan Liu; Wei Huang; Qiang Zhao

doi:10.1039/c7mh00726d

Photothermal-triggered release of singlet oxygen from an endoperoxide-containing polymeric carrier for killing cancer cells

Wen Lv
, Huiting Xia
, Kenneth Yin Zhang
, Zejing Chen
, Shujuan Liu
, Wei Huang
, Qiang Zhao

Institute of Flexible Electronics

Nanjing University of Posts and Telecommunications

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

A polymeric carrier containing a naphthalene and iridium(iii) complex was developed to deliver extracellular singlet oxygen (¹O₂) into cancer cells to induce oxidative damage without intracellular O₂ consumption. The release of ¹O₂ was triggered by the photothermal effect of Au nanorods upon irradiation at 808 nm, realizing controllable therapy combining both oxidative and photothermal damage.

Original language	English
Pages (from-to)	1185-1189
Number of pages	5
Journal	Materials Horizons
Volume	4
Issue number	6
DOIs	https://doi.org/10.1039/c7mh00726d
State	Published - Nov 2017

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SDG 3 Good Health and Well-being

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10.1039/c7mh00726d

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title = "Photothermal-triggered release of singlet oxygen from an endoperoxide-containing polymeric carrier for killing cancer cells",

abstract = "A polymeric carrier containing a naphthalene and iridium(iii) complex was developed to deliver extracellular singlet oxygen (1O2) into cancer cells to induce oxidative damage without intracellular O2 consumption. The release of 1O2 was triggered by the photothermal effect of Au nanorods upon irradiation at 808 nm, realizing controllable therapy combining both oxidative and photothermal damage.",

author = "Wen Lv and Huiting Xia and Zhang, \{Kenneth Yin\} and Zejing Chen and Shujuan Liu and Wei Huang and Qiang Zhao",

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year = "2017",

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doi = "10.1039/c7mh00726d",

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AU - Lv, Wen

AU - Xia, Huiting

AU - Zhang, Kenneth Yin

AU - Chen, Zejing

AU - Liu, Shujuan

AU - Huang, Wei

AU - Zhao, Qiang

PY - 2017/11

Y1 - 2017/11

N2 - A polymeric carrier containing a naphthalene and iridium(iii) complex was developed to deliver extracellular singlet oxygen (1O2) into cancer cells to induce oxidative damage without intracellular O2 consumption. The release of 1O2 was triggered by the photothermal effect of Au nanorods upon irradiation at 808 nm, realizing controllable therapy combining both oxidative and photothermal damage.

AB - A polymeric carrier containing a naphthalene and iridium(iii) complex was developed to deliver extracellular singlet oxygen (1O2) into cancer cells to induce oxidative damage without intracellular O2 consumption. The release of 1O2 was triggered by the photothermal effect of Au nanorods upon irradiation at 808 nm, realizing controllable therapy combining both oxidative and photothermal damage.

UR - https://www.scopus.com/pages/publications/85032742994

U2 - 10.1039/c7mh00726d

DO - 10.1039/c7mh00726d

M3 - 文章

AN - SCOPUS:85032742994

SN - 2051-6347

VL - 4

SP - 1185

EP - 1189

JO - Materials Horizons

JF - Materials Horizons

IS - 6

ER -

Photothermal-triggered release of singlet oxygen from an endoperoxide-containing polymeric carrier for killing cancer cells

Abstract

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