Morphology of apoptosis of human hepatocellular carcinoma cell line induced by 2-[(3-carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose

AIM: To investigate the changes of apoptosis in hepatocellular carcinoma cells induced by 2-[(3-carboxy-1-oxoprogyl) amino]-2-deoxy-D-glucose. METHODS: Fluorescent microscopy and transmission electron microscopy were used to observe the morphologic changes of apoptosis with different concentration of 2-[(3-carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose at different time. RESULTS: The morphologic changes of apoptosis were exhibited, including shrinkage of cell, condensation of chromatin, breakage of nuclear and formation of apoptotic bodies, but the number of apoptosis increased with the concentration 2-[(3-carboxy-1-oxoprogyl) amino]-2-deoxy-D-glucose and time. CONCLUSION: 2-[(3-carboxy-1-oxoprogy1) amino]-2-deoxy-D-glucose can induce apoptosis of human hepatocelluar carcinoma cells (HepG2).