Microfluidic device based on deep reactive ion etching process and its lag effect for single cell capture and extraction

Jianguo Feng; Zdenka Fohlerová; Xiaocheng Liu; Honglong Chang; Pavel Neužil

doi:10.1016/j.snb.2018.04.179

Microfluidic device based on deep reactive ion etching process and its lag effect for single cell capture and extraction

Jianguo Feng, Zdenka Fohlerová, Xiaocheng Liu, Honglong Chang, Pavel Neužil

School of Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We introduced a microfluidic device for high-efficiency single cell capture and their subsequent extraction. It was fabricated by using a deep reactive ion etching process taking advantage of the lag effect. We accomplished single cell capture based on the least flow resistance path principle as well as independent extraction of individual captured cells to perform their subsequent analysis. The device was performed with >99% single cell capture efficiency.

Original language	English
Pages (from-to)	288-292
Number of pages	5
Journal	Sensors and Actuators, B: Chemical
Volume	269
DOIs	https://doi.org/10.1016/j.snb.2018.04.179
State	Published - 15 Sep 2018

Keywords

Deep reactive ion etching
Lag effect
Microfluidic device
Single cell capture and extraction
The least flow resistance path

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10.1016/j.snb.2018.04.179

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abstract = "We introduced a microfluidic device for high-efficiency single cell capture and their subsequent extraction. It was fabricated by using a deep reactive ion etching process taking advantage of the lag effect. We accomplished single cell capture based on the least flow resistance path principle as well as independent extraction of individual captured cells to perform their subsequent analysis. The device was performed with >99% single cell capture efficiency.",

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AU - Feng, Jianguo

AU - Fohlerová, Zdenka

AU - Liu, Xiaocheng

AU - Chang, Honglong

AU - Neužil, Pavel

PY - 2018/9/15

Y1 - 2018/9/15

N2 - We introduced a microfluidic device for high-efficiency single cell capture and their subsequent extraction. It was fabricated by using a deep reactive ion etching process taking advantage of the lag effect. We accomplished single cell capture based on the least flow resistance path principle as well as independent extraction of individual captured cells to perform their subsequent analysis. The device was performed with >99% single cell capture efficiency.

AB - We introduced a microfluidic device for high-efficiency single cell capture and their subsequent extraction. It was fabricated by using a deep reactive ion etching process taking advantage of the lag effect. We accomplished single cell capture based on the least flow resistance path principle as well as independent extraction of individual captured cells to perform their subsequent analysis. The device was performed with >99% single cell capture efficiency.

KW - Deep reactive ion etching

KW - Lag effect

KW - Microfluidic device

KW - Single cell capture and extraction

KW - The least flow resistance path

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JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

ER -

Microfluidic device based on deep reactive ion etching process and its lag effect for single cell capture and extraction

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Keywords

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