Abstract
This commentary highlights the findings by Mai, et al. that ironomycin, derivatives of salinomycin, exhibited more potent and selective therapeutic activity against breast cancer stem cells by accumulating and sequestering iron in lysosome, followed by an iron-mediated lysosomal production of reactive oxygen species and an iron-dependent cell death. These unprecedented findings identified iron homeostasis and iron-mediated processes as potentially druggable in the context of cancer stem cells.
| Original language | English |
|---|---|
| Article number | 79 |
| Journal | Journal of Experimental and Clinical Cancer Research |
| Volume | 37 |
| Issue number | 1 |
| DOIs | |
| State | Published - 10 Apr 2018 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cancer stem cells
- Cell death
- Executioner
- Iron
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