Insulin-like growth factor binding protein-1 inhibits cancer cell invasion and is associated with poor prognosis in hepatocellular carcinoma

Bin Dai, Bai Ruan, Juan Wu, Jianlin Wang, Runze Shang, Wei Sun, Xia Li, Kefeng Dou, Desheng Wang, Yu Li

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Insulin-like growth factor binding protein-1 (IGFBP-1) plays an important role in the development and progression of cancer. However, the expression of IGFBP-1 remains equivocal, and little is known about its clinicopathological significance and prognostic value in hepatocellular carcinoma (HCC). In this study, we evaluated the expression of IGFBP-1 in 90 paired HCC tissues and adjacent non-cancerous liver tissues and analyzed its clinical and prognostic significance. The results showed that IGFBP-1 was detected in cytoplasm as well as cell nucleus, and down-regulated in HCC tissues compared to the adjacent non-cancerous liver tissues. The decreased expression of IGFBP-1 was correlated with tumor differentiation, liver cirrhosis, microvascular invasion or metastasis, TNM stage and poor survival. Moreover, low levels of IGFBP-1 may be an independent prognostic indicator for the survival of patients with HCC. We also evaluated its function by adding recombinant IGFBP-1 to the cultured HCC cell lines HepG2 and MHCC97-H. The result of the invasion chamber assay showed that IGFBP-1 could inhibit the invasion of HepG2 and MHCC97-H. MMP-9 secretion by these cells was significantly decreased when the cells were treated with IGFBP-1. Our results suggest that IGFBP-1 inhibits the invasion and metastasis of HCC cells and that IGFBP-1 may be useful as a valuable marker for the prognosis of patients with HCC.

Original languageEnglish
Pages (from-to)5645-5654
Number of pages10
JournalInternational Journal of Clinical and Experimental Pathology
Volume7
Issue number9
StatePublished - 2014
Externally publishedYes

Keywords

  • Hepatocellular carcinoma
  • IGFBP-1
  • Invasion
  • MMP-9
  • Poor prognosis
  • Tumor suppressor gene

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