Inhibitory activity of the extract from broussonetia papyrifera fruits to cellular lipid peroxidation in vitro

On the basis of our previous work on the antioxidant and anticancer activities of the extract of the Broussonetia papyrifera fruits, in vitro inhibitory activity of the extract to cellular lipid peroxidation was under study in present work. Inhibitory activity of the extract was evaluated by determining the ability to inhibit H2O2-induced erythrocyte hemolysis and lipid peroxidation of liver homogenate, to inhibit mitochondrial swelling and to scavenge hydroxyl radical. The total flavonoid content was found to be 75.46 ± 1.91 mg rutin equivalents g-1 lyophilized extract. The extract was a potent inhibitor of erythrocyte hemolysis, lipid peroxidation and mitochondrial swelling and was a scavenger of hydroxyl radical. The inhibitory activity of the extract showed a dose-dependent increase in the assays. This study suggested the extract was a potent antioxidant and might be developed as a potential botanical medicine or functional food.