Implantable Biophotonic Device for Wirelessly Cancer Real-Time Monitoring and Modulable Treatment

Miniaturized bio-devices present a promising solution to address the limitations of conventional therapeutic equipment, such as bulkiness and high cost, while facilitating continuous monitoring of cancer development and treatment progression. Herein, a flexible wirelessly implantable biophotonic device is developed via integrating an oxyhemoglobin saturation (sO₂) sensing probe, a low-power Bluetooth microcontroller unit, and a wireless power module on a flexible printed circuit board. It is fabricated to identify tumors (˂ 30 mm³) from normal tissues by monitoring sO₂ levels indicative of the tumor hypoxic microenvironment. Furthermore, this device can also evaluate the therapeutic progression of chemotherapy drugs like vadimezan, which reduces sO₂ levels by disrupting tumor angiogenesis. The µ-LED in the biophotonic device can function as a light source for in situ photodynamic therapy while simultaneously monitoring the oxygen consumption during the treatment process. The biophotonic device is lightweight, thin, and flexible, allowing seamless implantation within the body. It operates via wireless power and data transmission without disrupting normal physiological activities. Hence, the biophotonic device is capable of concurrently achieving precise tumor discrimination, modulable in situ treatments, and real-time progression monitoring, enabling the evaluation and optimization of therapeutic efficacy.