Identification and characterization of lipopeptides as a potential wound healing agent produced by Bacillus subtilis

Lu Yan; Guanwen Liu; Xinglong Wang; Chunmei Jiang; Dongyan Shao; Junling Shi

Identification and characterization of lipopeptides as a potential wound healing agent produced by Bacillus subtilis

Lu Yan
, Guanwen Liu
, Xinglong Wang
, Chunmei Jiang
, Dongyan Shao
, Junling Shi

School of life sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Wound healing is an intricate and orchestrated process composed of inflammation, tissue formation, and remodeling phases, and is delayed in some cases, such as diabetes. Although some drugs have been applied to clinical use, the availability of drugs to promote the wound healing is required. Lipopeptides produced by Bacillus subtilis are famous for their antimicrobial activities, however, no report of lipopeptides has been found on affecting wound healing. The aim of our study is to determine the possibility of lipopeptides on wound healing. Results indicated that lipopeptides produced by B. subtilis markedly accelerated wound healing on the rabbit skin, and regulated inflammation reaction at the wound site by increasing the expression of TGF-β2 and IL-6. In conclusion, the function of lipopeptides might indicate the possibility of its clinical use for wound therapy.

Original language	English
Title of host publication	3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019
Publisher	VDE Verlag GmbH
Pages	521-524
Number of pages	4
ISBN (Electronic)	9783800750269
State	Published - 2019
Event	3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019 - Hangzhou, China Duration: 20 Jul 2019 → 22 Jul 2019

Publication series

Name	3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019

Conference

Conference	3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019
Country/Territory	China
City	Hangzhou
Period	20/07/19 → 22/07/19

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cite this

Yan, L., Liu, G., Wang, X., Jiang, C., Shao, D., & Shi, J. (2019). Identification and characterization of lipopeptides as a potential wound healing agent produced by Bacillus subtilis. In 3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019 (pp. 521-524). (3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019). VDE Verlag GmbH.

Yan, Lu ; Liu, Guanwen ; Wang, Xinglong et al. / Identification and characterization of lipopeptides as a potential wound healing agent produced by Bacillus subtilis. 3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019. VDE Verlag GmbH, 2019. pp. 521-524 (3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019).

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title = "Identification and characterization of lipopeptides as a potential wound healing agent produced by Bacillus subtilis",

abstract = "Wound healing is an intricate and orchestrated process composed of inflammation, tissue formation, and remodeling phases, and is delayed in some cases, such as diabetes. Although some drugs have been applied to clinical use, the availability of drugs to promote the wound healing is required. Lipopeptides produced by Bacillus subtilis are famous for their antimicrobial activities, however, no report of lipopeptides has been found on affecting wound healing. The aim of our study is to determine the possibility of lipopeptides on wound healing. Results indicated that lipopeptides produced by B. subtilis markedly accelerated wound healing on the rabbit skin, and regulated inflammation reaction at the wound site by increasing the expression of TGF-β2 and IL-6. In conclusion, the function of lipopeptides might indicate the possibility of its clinical use for wound therapy.",

author = "Lu Yan and Guanwen Liu and Xinglong Wang and Chunmei Jiang and Dongyan Shao and Junling Shi",

note = "Publisher Copyright: {\textcopyright} VDE VERLAG GMBH · Berlin · Offenbach.; 3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019 ; Conference date: 20-07-2019 Through 22-07-2019",

year = "2019",

language = "英语",

series = "3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019",

publisher = "VDE Verlag GmbH",

pages = "521--524",

booktitle = "3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019",

}

Yan, L, Liu, G, Wang, X, Jiang, C, Shao, D & Shi, J 2019, Identification and characterization of lipopeptides as a potential wound healing agent produced by Bacillus subtilis. in 3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019. 3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019, VDE Verlag GmbH, pp. 521-524, 3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019, Hangzhou, China, 20/07/19.

Identification and characterization of lipopeptides as a potential wound healing agent produced by Bacillus subtilis. / Yan, Lu; Liu, Guanwen; Wang, Xinglong et al.
3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019. VDE Verlag GmbH, 2019. p. 521-524 (3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Identification and characterization of lipopeptides as a potential wound healing agent produced by Bacillus subtilis

AU - Yan, Lu

AU - Liu, Guanwen

AU - Wang, Xinglong

AU - Jiang, Chunmei

AU - Shao, Dongyan

AU - Shi, Junling

PY - 2019

Y1 - 2019

N2 - Wound healing is an intricate and orchestrated process composed of inflammation, tissue formation, and remodeling phases, and is delayed in some cases, such as diabetes. Although some drugs have been applied to clinical use, the availability of drugs to promote the wound healing is required. Lipopeptides produced by Bacillus subtilis are famous for their antimicrobial activities, however, no report of lipopeptides has been found on affecting wound healing. The aim of our study is to determine the possibility of lipopeptides on wound healing. Results indicated that lipopeptides produced by B. subtilis markedly accelerated wound healing on the rabbit skin, and regulated inflammation reaction at the wound site by increasing the expression of TGF-β2 and IL-6. In conclusion, the function of lipopeptides might indicate the possibility of its clinical use for wound therapy.

AB - Wound healing is an intricate and orchestrated process composed of inflammation, tissue formation, and remodeling phases, and is delayed in some cases, such as diabetes. Although some drugs have been applied to clinical use, the availability of drugs to promote the wound healing is required. Lipopeptides produced by Bacillus subtilis are famous for their antimicrobial activities, however, no report of lipopeptides has been found on affecting wound healing. The aim of our study is to determine the possibility of lipopeptides on wound healing. Results indicated that lipopeptides produced by B. subtilis markedly accelerated wound healing on the rabbit skin, and regulated inflammation reaction at the wound site by increasing the expression of TGF-β2 and IL-6. In conclusion, the function of lipopeptides might indicate the possibility of its clinical use for wound therapy.

UR - https://www.scopus.com/pages/publications/85096511830

M3 - 会议稿件

AN - SCOPUS:85096511830

T3 - 3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019

SP - 521

EP - 524

BT - 3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019

PB - VDE Verlag GmbH

T2 - 3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019

Y2 - 20 July 2019 through 22 July 2019

ER -

Yan L, Liu G, Wang X, Jiang C, Shao D, Shi J. Identification and characterization of lipopeptides as a potential wound healing agent produced by Bacillus subtilis. In 3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019. VDE Verlag GmbH. 2019. p. 521-524. (3rd International Conference on Biological Information and Biomedical Engineering, BIBE 2019).

Identification and characterization of lipopeptides as a potential wound healing agent produced by Bacillus subtilis

Abstract

Publication series

Conference

UN SDGs

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