Genetic basis of ruminant headgear and rapid antler regeneration

Yu Wang; Chenzhou Zhang; Nini Wang; Zhipeng Li; Rasmus Heller; Rong Liu; Yue Zhao; Jiangang Han; Xiangyu Pan; Zhuqing Zheng; Xueqin Dai; Ceshi Chen; Mingle Dou; Shujun Peng; Xianqing Chen; Jing Liu; Ming Li; Kun Wang; Chang Liu; Zeshan Lin; Lei Chen; Fei Hao; Wenbo Zhu; Chengchuang Song; Chen Zhao; Chengli Zheng; Jianming Wang; Shengwei Hu; Cunyuan Li; Hui Yang; Lin Jiang; Guangyu Li; Mingjun Liu; Tad S. Sonstegard; Guojie Zhang; Yu Jiang; Wen Wang; Qiang Qiu

doi:10.1126/science.aav6335

Genetic basis of ruminant headgear and rapid antler regeneration

Yu Wang
, Chenzhou Zhang
, Nini Wang
, Zhipeng Li
, Rasmus Heller
, Rong Liu
, Yue Zhao
, Jiangang Han
, Xiangyu Pan
, Zhuqing Zheng
, Xueqin Dai
, Ceshi Chen
, Mingle Dou
, Shujun Peng
, Xianqing Chen
, Jing Liu
, Ming Li
, Kun Wang
, Chang Liu
, Zeshan Lin

Lei Chen, Fei Hao, Wenbo Zhu, Chengchuang Song, Chen Zhao, Chengli Zheng, Jianming Wang, Shengwei Hu, Cunyuan Li, Hui Yang, Lin Jiang, Guangyu Li, Mingjun Liu, Tad S. Sonstegard, Guojie Zhang, Yu Jiang, Wen Wang, Qiang Qiu

Northwest Agriculture and Forestry University
Northwestern Polytechnical University Xian
Chinese Academy of Agricultural Sciences
University of Copenhagen
CAS - Kunming Institute of Zoology
Chinese Academy of Sciences
Sichuan Institute of Musk Deer Breeding
Shihezi University
Xinjiang Academy of Animal Science
Recombinetics Inc
BGI-Shenzhen

Research output: Contribution to journal › Article › peer-review

171 Scopus citations

Abstract

Ruminants are the only extant mammalian group possessing bony (osseous) headgear. We obtained 221 transcriptomes from bovids and cervids and sequenced three genomes representing the only two pecoran lineages that convergently lack headgear. Comparative analyses reveal that bovid horns and cervid antlers share similar gene expression profiles and a common cellular basis developed from neural crest stem cells. The rapid regenerative properties of antler tissue involve exploitation of oncogenetic pathways, and at the same time some tumor suppressor genes are under strong selection in deer. These results provide insights into the evolutionary origin of ruminant headgear as well as mammalian organ regeneration and oncogenesis.

Original language	English
Article number	Y
Journal	Science
Volume	364
Issue number	6446
DOIs	https://doi.org/10.1126/science.aav6335
State	Published - 2019

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title = "Genetic basis of ruminant headgear and rapid antler regeneration",

abstract = "Ruminants are the only extant mammalian group possessing bony (osseous) headgear. We obtained 221 transcriptomes from bovids and cervids and sequenced three genomes representing the only two pecoran lineages that convergently lack headgear. Comparative analyses reveal that bovid horns and cervid antlers share similar gene expression profiles and a common cellular basis developed from neural crest stem cells. The rapid regenerative properties of antler tissue involve exploitation of oncogenetic pathways, and at the same time some tumor suppressor genes are under strong selection in deer. These results provide insights into the evolutionary origin of ruminant headgear as well as mammalian organ regeneration and oncogenesis.",

author = "Yu Wang and Chenzhou Zhang and Nini Wang and Zhipeng Li and Rasmus Heller and Rong Liu and Yue Zhao and Jiangang Han and Xiangyu Pan and Zhuqing Zheng and Xueqin Dai and Ceshi Chen and Mingle Dou and Shujun Peng and Xianqing Chen and Jing Liu and Ming Li and Kun Wang and Chang Liu and Zeshan Lin and Lei Chen and Fei Hao and Wenbo Zhu and Chengchuang Song and Chen Zhao and Chengli Zheng and Jianming Wang and Shengwei Hu and Cunyuan Li and Hui Yang and Lin Jiang and Guangyu Li and Mingjun Liu and Sonstegard, \{Tad S.\} and Guojie Zhang and Yu Jiang and Wen Wang and Qiang Qiu",

year = "2019",

doi = "10.1126/science.aav6335",

language = "英语",

volume = "364",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6446",

}

Wang, Y, Zhang, C, Wang, N, Li, Z, Heller, R, Liu, R, Zhao, Y, Han, J, Pan, X, Zheng, Z, Dai, X, Chen, C, Dou, M, Peng, S, Chen, X, Liu, J, Li, M, Wang, K, Liu, C, Lin, Z, Chen, L, Hao, F, Zhu, W, Song, C, Zhao, C, Zheng, C, Wang, J, Hu, S, Li, C, Yang, H, Jiang, L, Li, G, Liu, M, Sonstegard, TS, Zhang, G, Jiang, Y, Wang, W & Qiu, Q 2019, 'Genetic basis of ruminant headgear and rapid antler regeneration', Science, vol. 364, no. 6446, Y. https://doi.org/10.1126/science.aav6335

TY - JOUR

T1 - Genetic basis of ruminant headgear and rapid antler regeneration

AU - Wang, Yu

AU - Zhang, Chenzhou

AU - Wang, Nini

AU - Li, Zhipeng

AU - Heller, Rasmus

AU - Liu, Rong

AU - Zhao, Yue

AU - Han, Jiangang

AU - Pan, Xiangyu

AU - Zheng, Zhuqing

AU - Dai, Xueqin

AU - Chen, Ceshi

AU - Dou, Mingle

AU - Peng, Shujun

AU - Chen, Xianqing

AU - Liu, Jing

AU - Li, Ming

AU - Wang, Kun

AU - Liu, Chang

AU - Lin, Zeshan

AU - Chen, Lei

AU - Hao, Fei

AU - Zhu, Wenbo

AU - Song, Chengchuang

AU - Zhao, Chen

AU - Zheng, Chengli

AU - Wang, Jianming

AU - Hu, Shengwei

AU - Li, Cunyuan

AU - Yang, Hui

AU - Jiang, Lin

AU - Li, Guangyu

AU - Liu, Mingjun

AU - Sonstegard, Tad S.

AU - Zhang, Guojie

AU - Jiang, Yu

AU - Wang, Wen

AU - Qiu, Qiang

PY - 2019

Y1 - 2019

N2 - Ruminants are the only extant mammalian group possessing bony (osseous) headgear. We obtained 221 transcriptomes from bovids and cervids and sequenced three genomes representing the only two pecoran lineages that convergently lack headgear. Comparative analyses reveal that bovid horns and cervid antlers share similar gene expression profiles and a common cellular basis developed from neural crest stem cells. The rapid regenerative properties of antler tissue involve exploitation of oncogenetic pathways, and at the same time some tumor suppressor genes are under strong selection in deer. These results provide insights into the evolutionary origin of ruminant headgear as well as mammalian organ regeneration and oncogenesis.

AB - Ruminants are the only extant mammalian group possessing bony (osseous) headgear. We obtained 221 transcriptomes from bovids and cervids and sequenced three genomes representing the only two pecoran lineages that convergently lack headgear. Comparative analyses reveal that bovid horns and cervid antlers share similar gene expression profiles and a common cellular basis developed from neural crest stem cells. The rapid regenerative properties of antler tissue involve exploitation of oncogenetic pathways, and at the same time some tumor suppressor genes are under strong selection in deer. These results provide insights into the evolutionary origin of ruminant headgear as well as mammalian organ regeneration and oncogenesis.

UR - https://www.scopus.com/pages/publications/85068581970

U2 - 10.1126/science.aav6335

DO - 10.1126/science.aav6335

M3 - 文章

C2 - 31221830

AN - SCOPUS:85068581970

SN - 0036-8075

VL - 364

JO - Science

JF - Science

IS - 6446

M1 - Y

ER -

Genetic basis of ruminant headgear and rapid antler regeneration

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