Efficient preparation of polyfunctional indoles via a zinc organometallic variation of the Fischer indole synthesis

Zhi Guang Zhang; Benjamin A. Haag; Jin Shan Li; Paul Knochel

doi:10.1055/s-0030-1258348

Efficient preparation of polyfunctional indoles via a zinc organometallic variation of the Fischer indole synthesis

Zhi Guang Zhang
, Benjamin A. Haag
, Jin Shan Li
, Paul Knochel

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Functionalized organozinc reagents readily react with various aryldiazonium salts furnishing regioselectively polyfunctional indoles after heating with microwave irradiation. This new organometallic variation of the Fischer indole synthesis tolerates a wide range of functional groups and can be readily scaled up.

Original language	English
Pages (from-to)	23-29
Number of pages	7
Journal	Synthesis
Issue number	1
DOIs	https://doi.org/10.1055/s-0030-1258348
State	Published - 2011
Externally published	Yes

Keywords

Fischer indole synthesis
N-heterocycles
indoles
organozinc reagents
regioselectivity

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10.1055/s-0030-1258348

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title = "Efficient preparation of polyfunctional indoles via a zinc organometallic variation of the Fischer indole synthesis",

abstract = "Functionalized organozinc reagents readily react with various aryldiazonium salts furnishing regioselectively polyfunctional indoles after heating with microwave irradiation. This new organometallic variation of the Fischer indole synthesis tolerates a wide range of functional groups and can be readily scaled up.",

keywords = "Fischer indole synthesis, N-heterocycles, indoles, organozinc reagents, regioselectivity",

author = "Zhang, \{Zhi Guang\} and Haag, \{Benjamin A.\} and Li, \{Jin Shan\} and Paul Knochel",

year = "2011",

doi = "10.1055/s-0030-1258348",

language = "英语",

pages = "23--29",

journal = "Synthesis",

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T1 - Efficient preparation of polyfunctional indoles via a zinc organometallic variation of the Fischer indole synthesis

AU - Zhang, Zhi Guang

AU - Haag, Benjamin A.

AU - Li, Jin Shan

AU - Knochel, Paul

PY - 2011

Y1 - 2011

N2 - Functionalized organozinc reagents readily react with various aryldiazonium salts furnishing regioselectively polyfunctional indoles after heating with microwave irradiation. This new organometallic variation of the Fischer indole synthesis tolerates a wide range of functional groups and can be readily scaled up.

AB - Functionalized organozinc reagents readily react with various aryldiazonium salts furnishing regioselectively polyfunctional indoles after heating with microwave irradiation. This new organometallic variation of the Fischer indole synthesis tolerates a wide range of functional groups and can be readily scaled up.

KW - Fischer indole synthesis

KW - N-heterocycles

KW - indoles

KW - organozinc reagents

KW - regioselectivity

UR - https://www.scopus.com/pages/publications/78650501807

U2 - 10.1055/s-0030-1258348

DO - 10.1055/s-0030-1258348

M3 - 文章

AN - SCOPUS:78650501807

SN - 0039-7881

SP - 23

EP - 29

JO - Synthesis

JF - Synthesis

IS - 1

ER -

Efficient preparation of polyfunctional indoles via a zinc organometallic variation of the Fischer indole synthesis

Abstract

Keywords

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