Effect of Hydrophilic Monomer Distribution on Self-Assembly of a pH-Responsive Copolymer: Spheres, Worms and Vesicles from a Single Copolymer Composition

Junliang Zhang; Barbara Farias-Mancilla; Ihor Kulai; Stephanie Hoeppener; Barbara Lonetti; Sylvain Prévost; Jens Ulbrich; Mathias Destarac; Olivier Colombani; Ulrich S. Schubert; Carlos Guerrero-Sanchez; Simon Harrisson

doi:10.1002/anie.202010501

Effect of Hydrophilic Monomer Distribution on Self-Assembly of a pH-Responsive Copolymer: Spheres, Worms and Vesicles from a Single Copolymer Composition

Junliang Zhang
, Barbara Farias-Mancilla
, Ihor Kulai
, Stephanie Hoeppener
, Barbara Lonetti
, Sylvain Prévost
, Jens Ulbrich
, Mathias Destarac
, Olivier Colombani
, Ulrich S. Schubert
, Carlos Guerrero-Sanchez
, Simon Harrisson

School of Chemistry and Chemical Engineering

Friedrich Schiller University Jena
Université Paul Sabatier
Institut Laue-Langevin
Institut des Molécules et Matériaux du Mans
Université de Bordeaux

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

A series of copolymers containing 50 mol % acrylic acid (AA) and 50 mol % butyl acrylate (BA) but with differing composition profiles ranging from an AA-BA diblock copolymer to a linear gradient poly(AA-grad-BA) copolymer were synthesized and their pH-responsive self-assembly behavior was investigated. While assemblies of the AA-BA diblock copolymer were kinetically frozen, the gradient-like compositions underwent reversible changes in size and morphology in response to changes in pH. In particular, a diblock copolymer consisting of two random copolymer segments of equal length (16 mol % and 84 mol % AA content, respectively) formed spherical micelles at pH >5, a mix of spherical and wormlike micelles at pH 5 and vesicles at pH 4. These assemblies were characterized by dynamic light scattering, cryo-transmission electron microscopy and small angle neutron scattering.

Original language	English
Pages (from-to)	4925-4930
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	60
Issue number	9
DOIs	https://doi.org/10.1002/anie.202010501
State	Published - 23 Feb 2021

Keywords

copolymer
gradient copolymer
self-assembly
sequence control
stimuli-responsive

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10.1002/anie.202010501

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Zhang, J., Farias-Mancilla, B., Kulai, I., Hoeppener, S., Lonetti, B., Prévost, S., Ulbrich, J., Destarac, M., Colombani, O., Schubert, U. S., Guerrero-Sanchez, C., & Harrisson, S. (2021). Effect of Hydrophilic Monomer Distribution on Self-Assembly of a pH-Responsive Copolymer: Spheres, Worms and Vesicles from a Single Copolymer Composition. Angewandte Chemie - International Edition, 60(9), 4925-4930. https://doi.org/10.1002/anie.202010501

@article{33445cfcd50649deade9107ca65a785a,

title = "Effect of Hydrophilic Monomer Distribution on Self-Assembly of a pH-Responsive Copolymer: Spheres, Worms and Vesicles from a Single Copolymer Composition",

abstract = "A series of copolymers containing 50 mol \% acrylic acid (AA) and 50 mol \% butyl acrylate (BA) but with differing composition profiles ranging from an AA-BA diblock copolymer to a linear gradient poly(AA-grad-BA) copolymer were synthesized and their pH-responsive self-assembly behavior was investigated. While assemblies of the AA-BA diblock copolymer were kinetically frozen, the gradient-like compositions underwent reversible changes in size and morphology in response to changes in pH. In particular, a diblock copolymer consisting of two random copolymer segments of equal length (16 mol \% and 84 mol \% AA content, respectively) formed spherical micelles at pH >5, a mix of spherical and wormlike micelles at pH 5 and vesicles at pH 4. These assemblies were characterized by dynamic light scattering, cryo-transmission electron microscopy and small angle neutron scattering.",

keywords = "copolymer, gradient copolymer, self-assembly, sequence control, stimuli-responsive",

author = "Junliang Zhang and Barbara Farias-Mancilla and Ihor Kulai and Stephanie Hoeppener and Barbara Lonetti and Sylvain Pr{\'e}vost and Jens Ulbrich and Mathias Destarac and Olivier Colombani and Schubert, \{Ulrich S.\} and Carlos Guerrero-Sanchez and Simon Harrisson",

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year = "2021",

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day = "23",

doi = "10.1002/anie.202010501",

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Zhang, J, Farias-Mancilla, B, Kulai, I, Hoeppener, S, Lonetti, B, Prévost, S, Ulbrich, J, Destarac, M, Colombani, O, Schubert, US, Guerrero-Sanchez, C & Harrisson, S 2021, 'Effect of Hydrophilic Monomer Distribution on Self-Assembly of a pH-Responsive Copolymer: Spheres, Worms and Vesicles from a Single Copolymer Composition', Angewandte Chemie - International Edition, vol. 60, no. 9, pp. 4925-4930. https://doi.org/10.1002/anie.202010501

Effect of Hydrophilic Monomer Distribution on Self-Assembly of a pH-Responsive Copolymer: Spheres, Worms and Vesicles from a Single Copolymer Composition. / Zhang, Junliang; Farias-Mancilla, Barbara; Kulai, Ihor et al.
In: Angewandte Chemie - International Edition, Vol. 60, No. 9, 23.02.2021, p. 4925-4930.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effect of Hydrophilic Monomer Distribution on Self-Assembly of a pH-Responsive Copolymer

T2 - Spheres, Worms and Vesicles from a Single Copolymer Composition

AU - Zhang, Junliang

AU - Farias-Mancilla, Barbara

AU - Kulai, Ihor

AU - Hoeppener, Stephanie

AU - Lonetti, Barbara

AU - Prévost, Sylvain

AU - Ulbrich, Jens

AU - Destarac, Mathias

AU - Colombani, Olivier

AU - Schubert, Ulrich S.

AU - Guerrero-Sanchez, Carlos

AU - Harrisson, Simon

PY - 2021/2/23

Y1 - 2021/2/23

N2 - A series of copolymers containing 50 mol % acrylic acid (AA) and 50 mol % butyl acrylate (BA) but with differing composition profiles ranging from an AA-BA diblock copolymer to a linear gradient poly(AA-grad-BA) copolymer were synthesized and their pH-responsive self-assembly behavior was investigated. While assemblies of the AA-BA diblock copolymer were kinetically frozen, the gradient-like compositions underwent reversible changes in size and morphology in response to changes in pH. In particular, a diblock copolymer consisting of two random copolymer segments of equal length (16 mol % and 84 mol % AA content, respectively) formed spherical micelles at pH >5, a mix of spherical and wormlike micelles at pH 5 and vesicles at pH 4. These assemblies were characterized by dynamic light scattering, cryo-transmission electron microscopy and small angle neutron scattering.

AB - A series of copolymers containing 50 mol % acrylic acid (AA) and 50 mol % butyl acrylate (BA) but with differing composition profiles ranging from an AA-BA diblock copolymer to a linear gradient poly(AA-grad-BA) copolymer were synthesized and their pH-responsive self-assembly behavior was investigated. While assemblies of the AA-BA diblock copolymer were kinetically frozen, the gradient-like compositions underwent reversible changes in size and morphology in response to changes in pH. In particular, a diblock copolymer consisting of two random copolymer segments of equal length (16 mol % and 84 mol % AA content, respectively) formed spherical micelles at pH >5, a mix of spherical and wormlike micelles at pH 5 and vesicles at pH 4. These assemblies were characterized by dynamic light scattering, cryo-transmission electron microscopy and small angle neutron scattering.

KW - copolymer

KW - gradient copolymer

KW - self-assembly

KW - sequence control

KW - stimuli-responsive

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DO - 10.1002/anie.202010501

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AN - SCOPUS:85096670509

SN - 1433-7851

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SP - 4925

EP - 4930

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 9

ER -

Effect of Hydrophilic Monomer Distribution on Self-Assembly of a pH-Responsive Copolymer: Spheres, Worms and Vesicles from a Single Copolymer Composition

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Keywords

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