Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe

Weining Niu; Ping Wu; Fei Chen; Jun Wang; Xiaoya Shang; Chunlan Xu

doi:10.1039/c6md00493h

Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe

Weining Niu, Ping Wu, Fei Chen, Jun Wang, Xiaoya Shang, Chunlan Xu

School of life sciences

Northwestern Polytechnical University Xian

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A high-throughput assay was developed to identify inhibitors of cystathionine β-synthase (CBS), which is one of three key enzymes involved in H₂S biosynthesis. Screening of 6491 natural compounds identified several selective CBS inhibitors, which suppressed the proliferation of HT29 cancer cells, with IC₅₀ values of less than 10 μM.

Original language	English
Pages (from-to)	198-201
Number of pages	4
Journal	MedChemComm
Volume	8
Issue number	1
DOIs	https://doi.org/10.1039/c6md00493h
State	Published - 2017

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10.1039/c6md00493h

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title = "Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe",

abstract = "A high-throughput assay was developed to identify inhibitors of cystathionine β-synthase (CBS), which is one of three key enzymes involved in H2S biosynthesis. Screening of 6491 natural compounds identified several selective CBS inhibitors, which suppressed the proliferation of HT29 cancer cells, with IC50 values of less than 10 μM.",

author = "Weining Niu and Ping Wu and Fei Chen and Jun Wang and Xiaoya Shang and Chunlan Xu",

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year = "2017",

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AU - Niu, Weining

AU - Wu, Ping

AU - Chen, Fei

AU - Wang, Jun

AU - Shang, Xiaoya

AU - Xu, Chunlan

PY - 2017

Y1 - 2017

N2 - A high-throughput assay was developed to identify inhibitors of cystathionine β-synthase (CBS), which is one of three key enzymes involved in H2S biosynthesis. Screening of 6491 natural compounds identified several selective CBS inhibitors, which suppressed the proliferation of HT29 cancer cells, with IC50 values of less than 10 μM.

AB - A high-throughput assay was developed to identify inhibitors of cystathionine β-synthase (CBS), which is one of three key enzymes involved in H2S biosynthesis. Screening of 6491 natural compounds identified several selective CBS inhibitors, which suppressed the proliferation of HT29 cancer cells, with IC50 values of less than 10 μM.

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U2 - 10.1039/c6md00493h

DO - 10.1039/c6md00493h

M3 - 文章

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SN - 2040-2503

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SP - 198

EP - 201

JO - MedChemComm

JF - MedChemComm

IS - 1

ER -

Discovery of selective cystathionine β-synthase inhibitors by high-throughput screening with a fluorescent thiol probe

Abstract

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