Comparison of the roles of estrogens and androgens in breast cancer and prostate cancer

Wen Jing Liu; Gang Zhao; Chen Yan Zhang; Chang Qing Yang; Xiang Bin Zeng; Jin Li; Kun Zhu; Shi Qi Zhao; Hui Meng Lu; Da Chuan Yin; Sheng Xiang Lin

doi:10.1002/jcb.29515

Comparison of the roles of estrogens and androgens in breast cancer and prostate cancer

Wen Jing Liu
, Gang Zhao
, Chen Yan Zhang
, Chang Qing Yang
, Xiang Bin Zeng
, Jin Li
, Kun Zhu
, Shi Qi Zhao
, Hui Meng Lu
, Da Chuan Yin
, Sheng Xiang Lin

School of life sciences

Northwestern Polytechnical University Xian
The First Hospital of Jilin University
Université Laval

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Breast cancer (BC) and prostate cancer (PC) are the second most common malignant tumors in women and men in western countries, respectively. The risks of death are 14% for BC and 9% for PC. Abnormal estrogen and androgen levels are related to carcinogenesis of the breast and prostate. Estradiol stimulates cancer development in BC. The effect of estrogen on PC is concentration-dependent, and estrogen can regulate androgen production, further affecting PC. Estrogen can also increase the risk of androgen-induced PC. Androgen has dual effects on BC via different metabolic pathways, and the role of the androgen receptor (AR) in BC also depends on cell subtype and downstream target genes. Androgen and AR can stimulate both primary PC and castration-resistant PC. Understanding the mechanisms of the effects of estrogen and androgen on BC and PC may help us to improve curative BC and PC treatment strategies.

Original language	English
Pages (from-to)	2756-2769
Number of pages	14
Journal	Journal of Cellular Biochemistry
Volume	121
Issue number	4
DOIs	https://doi.org/10.1002/jcb.29515
State	Published - 1 Apr 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

androgen
breast cancer
estrogen
prostate cancer

Access to Document

10.1002/jcb.29515

Cite this

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title = "Comparison of the roles of estrogens and androgens in breast cancer and prostate cancer",

abstract = "Breast cancer (BC) and prostate cancer (PC) are the second most common malignant tumors in women and men in western countries, respectively. The risks of death are 14\% for BC and 9\% for PC. Abnormal estrogen and androgen levels are related to carcinogenesis of the breast and prostate. Estradiol stimulates cancer development in BC. The effect of estrogen on PC is concentration-dependent, and estrogen can regulate androgen production, further affecting PC. Estrogen can also increase the risk of androgen-induced PC. Androgen has dual effects on BC via different metabolic pathways, and the role of the androgen receptor (AR) in BC also depends on cell subtype and downstream target genes. Androgen and AR can stimulate both primary PC and castration-resistant PC. Understanding the mechanisms of the effects of estrogen and androgen on BC and PC may help us to improve curative BC and PC treatment strategies.",

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year = "2020",

month = apr,

day = "1",

doi = "10.1002/jcb.29515",

language = "英语",

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journal = "Journal of Cellular Biochemistry",

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TY - JOUR

T1 - Comparison of the roles of estrogens and androgens in breast cancer and prostate cancer

AU - Liu, Wen Jing

AU - Zhao, Gang

AU - Zhang, Chen Yan

AU - Yang, Chang Qing

AU - Zeng, Xiang Bin

AU - Li, Jin

AU - Zhu, Kun

AU - Zhao, Shi Qi

AU - Lu, Hui Meng

AU - Yin, Da Chuan

AU - Lin, Sheng Xiang

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Breast cancer (BC) and prostate cancer (PC) are the second most common malignant tumors in women and men in western countries, respectively. The risks of death are 14% for BC and 9% for PC. Abnormal estrogen and androgen levels are related to carcinogenesis of the breast and prostate. Estradiol stimulates cancer development in BC. The effect of estrogen on PC is concentration-dependent, and estrogen can regulate androgen production, further affecting PC. Estrogen can also increase the risk of androgen-induced PC. Androgen has dual effects on BC via different metabolic pathways, and the role of the androgen receptor (AR) in BC also depends on cell subtype and downstream target genes. Androgen and AR can stimulate both primary PC and castration-resistant PC. Understanding the mechanisms of the effects of estrogen and androgen on BC and PC may help us to improve curative BC and PC treatment strategies.

AB - Breast cancer (BC) and prostate cancer (PC) are the second most common malignant tumors in women and men in western countries, respectively. The risks of death are 14% for BC and 9% for PC. Abnormal estrogen and androgen levels are related to carcinogenesis of the breast and prostate. Estradiol stimulates cancer development in BC. The effect of estrogen on PC is concentration-dependent, and estrogen can regulate androgen production, further affecting PC. Estrogen can also increase the risk of androgen-induced PC. Androgen has dual effects on BC via different metabolic pathways, and the role of the androgen receptor (AR) in BC also depends on cell subtype and downstream target genes. Androgen and AR can stimulate both primary PC and castration-resistant PC. Understanding the mechanisms of the effects of estrogen and androgen on BC and PC may help us to improve curative BC and PC treatment strategies.

KW - androgen

KW - breast cancer

KW - estrogen

KW - prostate cancer

UR - https://www.scopus.com/pages/publications/85074948168

U2 - 10.1002/jcb.29515

DO - 10.1002/jcb.29515

M3 - 文章

C2 - 31693255

AN - SCOPUS:85074948168

SN - 0730-2312

VL - 121

SP - 2756

EP - 2769

JO - Journal of Cellular Biochemistry

JF - Journal of Cellular Biochemistry

IS - 4

ER -

Comparison of the roles of estrogens and androgens in breast cancer and prostate cancer

Abstract

UN SDGs

Keywords

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