Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity

Peng Li; Chuncai Zhou; Shahrzad Rayatpisheh; Kai Ye; Yin Fun Poon; Paula T. Hammond; Hongwei Duan; Mary B. Chan-Park

doi:10.1002/adma.201104186

Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity

Peng Li
, Chuncai Zhou
, Shahrzad Rayatpisheh
, Kai Ye
, Yin Fun Poon
, Paula T. Hammond
, Hongwei Duan
, Mary B. Chan-Park

Nanyang Technological University
Massachusetts Institute of Technology

Research output: Contribution to journal › Article › peer-review

260 Scopus citations

Abstract

Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan-mimetic structure, show outstanding broad-spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell-wall constituents promotes penetration to reach the cytoplasmic membrane resulting in excellent antimicrobial activity and high selectivity.

Original language	English
Pages (from-to)	4130-4137
Number of pages	8
Journal	Advanced Materials
Volume	24
Issue number	30
DOIs	https://doi.org/10.1002/adma.201104186
State	Published - 8 Aug 2012
Externally published	Yes

Keywords

antimicrobial polymers
biocompatible
biomedical
chitosan
peptidopolysaccharide

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10.1002/adma.201104186

Cite this

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abstract = "Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan-mimetic structure, show outstanding broad-spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell-wall constituents promotes penetration to reach the cytoplasmic membrane resulting in excellent antimicrobial activity and high selectivity.",

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author = "Peng Li and Chuncai Zhou and Shahrzad Rayatpisheh and Kai Ye and Poon, \{Yin Fun\} and Hammond, \{Paula T.\} and Hongwei Duan and Chan-Park, \{Mary B.\}",

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AU - Zhou, Chuncai

AU - Rayatpisheh, Shahrzad

AU - Ye, Kai

AU - Poon, Yin Fun

AU - Hammond, Paula T.

AU - Duan, Hongwei

AU - Chan-Park, Mary B.

PY - 2012/8/8

Y1 - 2012/8/8

N2 - Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan-mimetic structure, show outstanding broad-spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell-wall constituents promotes penetration to reach the cytoplasmic membrane resulting in excellent antimicrobial activity and high selectivity.

AB - Facilely synthesized cationic peptidopolysaccharides, which have a bacterial peptidoglycan-mimetic structure, show outstanding broad-spectrum activities against clinically significant bacteria and fungi and low mammalian cytotoxicity. Their structural affinity with microbial cell-wall constituents promotes penetration to reach the cytoplasmic membrane resulting in excellent antimicrobial activity and high selectivity.

KW - antimicrobial polymers

KW - biocompatible

KW - biomedical

KW - chitosan

KW - peptidopolysaccharide

UR - https://www.scopus.com/pages/publications/84864598994

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DO - 10.1002/adma.201104186

M3 - 文章

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AN - SCOPUS:84864598994

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SP - 4130

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JO - Advanced Materials

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Cationic peptidopolysaccharides show excellent broad-spectrum antimicrobial activities and high selectivity

Abstract

Keywords

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