Carbene-Catalyzed Construction of Carbazoles from Enals and 2-Methyl-3-oxoacetate Indoles

Dehai Liu; Yaru Gao; Jie Huang; Zhenqian Fu; Wei Huang

doi:10.1021/acs.joc.8b02532

Carbene-Catalyzed Construction of Carbazoles from Enals and 2-Methyl-3-oxoacetate Indoles

Dehai Liu
, Yaru Gao
, Jie Huang
, Zhenqian Fu
, Wei Huang

Institute of Flexible Electronics

Nanjing Tech University

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Direct and rapid construction of carbazoles has been successfully developed via carbene-catalyzed oxidative formal [4 + 2] annulation of enals with 2-methyl-3-oxoacetate indoles. This metal-free reaction features a broad substrate scope, features good functional-group tolerance, proceeds under mild conditions, and can be easily scaled up.

Original language	English
Pages (from-to)	14210-14217
Number of pages	8
Journal	Journal of Organic Chemistry
Volume	83
Issue number	22
DOIs	https://doi.org/10.1021/acs.joc.8b02532
State	Published - 16 Nov 2018

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10.1021/acs.joc.8b02532

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title = "Carbene-Catalyzed Construction of Carbazoles from Enals and 2-Methyl-3-oxoacetate Indoles",

abstract = "Direct and rapid construction of carbazoles has been successfully developed via carbene-catalyzed oxidative formal [4 + 2] annulation of enals with 2-methyl-3-oxoacetate indoles. This metal-free reaction features a broad substrate scope, features good functional-group tolerance, proceeds under mild conditions, and can be easily scaled up.",

author = "Dehai Liu and Yaru Gao and Jie Huang and Zhenqian Fu and Wei Huang",

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T1 - Carbene-Catalyzed Construction of Carbazoles from Enals and 2-Methyl-3-oxoacetate Indoles

AU - Liu, Dehai

AU - Gao, Yaru

AU - Huang, Jie

AU - Fu, Zhenqian

AU - Huang, Wei

PY - 2018/11/16

Y1 - 2018/11/16

N2 - Direct and rapid construction of carbazoles has been successfully developed via carbene-catalyzed oxidative formal [4 + 2] annulation of enals with 2-methyl-3-oxoacetate indoles. This metal-free reaction features a broad substrate scope, features good functional-group tolerance, proceeds under mild conditions, and can be easily scaled up.

AB - Direct and rapid construction of carbazoles has been successfully developed via carbene-catalyzed oxidative formal [4 + 2] annulation of enals with 2-methyl-3-oxoacetate indoles. This metal-free reaction features a broad substrate scope, features good functional-group tolerance, proceeds under mild conditions, and can be easily scaled up.

UR - https://www.scopus.com/pages/publications/85056178701

U2 - 10.1021/acs.joc.8b02532

DO - 10.1021/acs.joc.8b02532

M3 - 文章

C2 - 30351940

AN - SCOPUS:85056178701

SN - 0022-3263

VL - 83

SP - 14210

EP - 14217

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 22

ER -

Carbene-Catalyzed Construction of Carbazoles from Enals and 2-Methyl-3-oxoacetate Indoles

Abstract

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