Bright NIR-II Fluorescent Small-Molecule Nanoparticles with Reduced Intermolecular Interaction for Targeted in Vivo Inflammation Imaging

Shangyu Chen; Wansu Zhang; Xinyue Jiang; Yaqi Guo; Pengfei Sun; Wenjun Wang; Quli Fan; Wei Huang

doi:10.1021/acsapm.1c01015

Bright NIR-II Fluorescent Small-Molecule Nanoparticles with Reduced Intermolecular Interaction for Targeted in Vivo Inflammation Imaging

Shangyu Chen, Wansu Zhang, Xinyue Jiang, Yaqi Guo, Pengfei Sun, Wenjun Wang, Quli Fan, Wei Huang

Institute of Flexible Electronics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Though biocompatible small-molecule-based NIR-II fluorescent nanoparticles (NPs) are highly desirable in fluorescence imaging (FI), the fluorescence quantum yield is relatively poor due to the significant aggregation-caused quenching and the heavy intermolecular interactions. Herein, we conveniently obtained bright NIR-II fluorescent small-molecule NPs (TQFPNs) fabricated from a polystyrene (PS)-modified fluorophore (TQF-PS). Our prepared PS-modified NPs displayed 3.2-fold higher emission intensity than that of non-PS polymer chain NPs (TQF@NPs) in vitro. Finally, bright and high-resolution NIR-II FI of a rheumatoid arthritis mouse model and a pneumonia mouse model using TQFPNs demonstrated its successful application for targeted in vivo inflammation imaging.

Original language	English
Pages (from-to)	5236-5242
Number of pages	7
Journal	ACS Applied Polymer Materials
Volume	3
Issue number	10
DOIs	https://doi.org/10.1021/acsapm.1c01015
State	Published - 8 Oct 2021

Keywords

enhanced NIR-II fluorescence
NIR-II
reduced intermolecular interaction
small-molecule nanoparticles
targeted inflammation imaging

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10.1021/acsapm.1c01015

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title = "Bright NIR-II Fluorescent Small-Molecule Nanoparticles with Reduced Intermolecular Interaction for Targeted in Vivo Inflammation Imaging",

abstract = "Though biocompatible small-molecule-based NIR-II fluorescent nanoparticles (NPs) are highly desirable in fluorescence imaging (FI), the fluorescence quantum yield is relatively poor due to the significant aggregation-caused quenching and the heavy intermolecular interactions. Herein, we conveniently obtained bright NIR-II fluorescent small-molecule NPs (TQFPNs) fabricated from a polystyrene (PS)-modified fluorophore (TQF-PS). Our prepared PS-modified NPs displayed 3.2-fold higher emission intensity than that of non-PS polymer chain NPs (TQF@NPs) in vitro. Finally, bright and high-resolution NIR-II FI of a rheumatoid arthritis mouse model and a pneumonia mouse model using TQFPNs demonstrated its successful application for targeted in vivo inflammation imaging.",

keywords = "enhanced NIR-II fluorescence, NIR-II, reduced intermolecular interaction, small-molecule nanoparticles, targeted inflammation imaging",

author = "Shangyu Chen and Wansu Zhang and Xinyue Jiang and Yaqi Guo and Pengfei Sun and Wenjun Wang and Quli Fan and Wei Huang",

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doi = "10.1021/acsapm.1c01015",

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T1 - Bright NIR-II Fluorescent Small-Molecule Nanoparticles with Reduced Intermolecular Interaction for Targeted in Vivo Inflammation Imaging

AU - Chen, Shangyu

AU - Zhang, Wansu

AU - Jiang, Xinyue

AU - Guo, Yaqi

AU - Sun, Pengfei

AU - Wang, Wenjun

AU - Fan, Quli

AU - Huang, Wei

PY - 2021/10/8

Y1 - 2021/10/8

N2 - Though biocompatible small-molecule-based NIR-II fluorescent nanoparticles (NPs) are highly desirable in fluorescence imaging (FI), the fluorescence quantum yield is relatively poor due to the significant aggregation-caused quenching and the heavy intermolecular interactions. Herein, we conveniently obtained bright NIR-II fluorescent small-molecule NPs (TQFPNs) fabricated from a polystyrene (PS)-modified fluorophore (TQF-PS). Our prepared PS-modified NPs displayed 3.2-fold higher emission intensity than that of non-PS polymer chain NPs (TQF@NPs) in vitro. Finally, bright and high-resolution NIR-II FI of a rheumatoid arthritis mouse model and a pneumonia mouse model using TQFPNs demonstrated its successful application for targeted in vivo inflammation imaging.

AB - Though biocompatible small-molecule-based NIR-II fluorescent nanoparticles (NPs) are highly desirable in fluorescence imaging (FI), the fluorescence quantum yield is relatively poor due to the significant aggregation-caused quenching and the heavy intermolecular interactions. Herein, we conveniently obtained bright NIR-II fluorescent small-molecule NPs (TQFPNs) fabricated from a polystyrene (PS)-modified fluorophore (TQF-PS). Our prepared PS-modified NPs displayed 3.2-fold higher emission intensity than that of non-PS polymer chain NPs (TQF@NPs) in vitro. Finally, bright and high-resolution NIR-II FI of a rheumatoid arthritis mouse model and a pneumonia mouse model using TQFPNs demonstrated its successful application for targeted in vivo inflammation imaging.

KW - enhanced NIR-II fluorescence

KW - NIR-II

KW - reduced intermolecular interaction

KW - small-molecule nanoparticles

KW - targeted inflammation imaging

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JO - ACS Applied Polymer Materials

JF - ACS Applied Polymer Materials

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ER -

Bright NIR-II Fluorescent Small-Molecule Nanoparticles with Reduced Intermolecular Interaction for Targeted in Vivo Inflammation Imaging

Abstract

Keywords

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