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BLSegMamba: An Optimized SegMamba Framework for msTBI Lesion Segmentation in MRI

  • Yueyue Zhu
  • , Xiaoyu Bai
  • , Haotian Jiang
  • , Geng Chen
  • Northwestern Polytechnical University Xian

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Moderate-to-Severe Traumatic Brain Injury (msTBI) often leads to complex and highly heterogeneous structural damage in the brain. Lesions may be focal or diffuse and can involve multiple tissue types, including gray matter, white matter, and cerebrospinal fluid. They also exhibit considerable variability in size, shape, spatial distribution, and hemispheric symmetry. This high degree of heterogeneity greatly increases the difficulty of automatic segmentation based on unimodal T1-weighted MRI. To address this challenge, we propose a customized optimization of the SegMamba architecture. The resulting optimized version, Brain Lesion SegMamba (BLSegMamba), retains the core structural components of SegMamba while integrating a more robust data augmentation strategy and a loss function specifically designed for the segmentation of msTBI lesions. On the final test dataset of the AIMS-TBI Challenge, our BLSegMamba achieves the top overall ranking after weighted aggregation of all evaluation metrics. Our code is publicly available at https://github.com/YueyueZhu/BLSegMamba.

Original languageEnglish
Title of host publicationSegmentation, Classification, and Synthesis for Brain Tumors and Traumatic Brain Injuries - MICCAI 2025 Challenges
Subtitle of host publicationBraTS-Lighthouse 2025 and AIMS-TBI 2025, Held in Conjunction with MICCAI 2025, Proceedings
EditorsSpyridon Bakas, Emily Dennis, Mehdi Astaraki, Ujjwal Baid, Gian Marco Conte, Martha Foltyn-Dumitru, Zhifan Jiang, Marius George Linguraru, Dominic Labella, Marie-Christin Metz, Udunna Anazodo, Maria Correia de Verdier, Florian Kofler, Hongwei Bran Li, Nazanin Maleki
PublisherSpringer Science and Business Media Deutschland GmbH
Pages301-310
Number of pages10
ISBN (Print)9783032163691
DOIs
StatePublished - 2026
EventBrain TumorS Lighthouse Cluster of Challenges, and the Automated Identification of Moderate-Severe Traumatic Brain Injury Lesions Challenge, BraTS 2025 and AIMS-TBI 2025, held in Conjunction International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2025 - Daejeon, Korea, Republic of
Duration: 23 Sep 202527 Sep 2025

Publication series

NameLecture Notes in Computer Science
Volume16377 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

ConferenceBrain TumorS Lighthouse Cluster of Challenges, and the Automated Identification of Moderate-Severe Traumatic Brain Injury Lesions Challenge, BraTS 2025 and AIMS-TBI 2025, held in Conjunction International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2025
Country/TerritoryKorea, Republic of
CityDaejeon
Period23/09/2527/09/25

Keywords

  • Mamba
  • Segmentation
  • U-net
  • msTBI

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