TY - JOUR
T1 - Biodegradable and biocompatible supramolecular polymers based on poly(ε-caprolactone-co-δ-valerolactone)-b-poly(lactide) block copolymers with different branched structures
T2 - Synthesis, crystallization and properties
AU - Jing, Zhanxin
AU - Huang, Xiaolan
AU - Li, Guifeng
AU - Liao, Mingneng
AU - Hong, Pengzhi
AU - Li, Yong
AU - Shi, Xuetao
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/12/5
Y1 - 2022/12/5
N2 - A novel biodegradable supramolecular polymer (SMP) was successfully synthesized via self-complementary quadruple hydrogen bonding-driven poly(ε-caprolactone-co-δ-valerolactone)-b-poly(lactide) (PCVL-b-PLA) block copolymers. The SMP structure was analyzed by 1H NMR, GPC and the gel content, and found that the formation of self-complementary quadruple hydrogen bonds between UPy dimers not only expanded the polymer molecular chain, but also formed a cross-linked network structure for three-arm or four-arm branched PCVL-b-PLLA block copolymers. The results of WAXD and DSC indicated that compared with the precursor, the crystallization ability of supramolecular polymer was suppressed, but the stereocomplexation was conducive to the SMP crystallization. The tensile strength, elongation at break and tensile modulus were highly tunable and range from 7.1 ∼ 25.3 MPa, 588 ∼ 1860 % and 9.1 ∼ 21.4 MPa, respectively. The branching structure and sterecomplexation significantly adjusted the hydrophilicity and degradation of SMP. In addition, the synthesized SMP were evaluated for their biocompatibility by performing MTT assay using mouse fibroblasts (L929), indicating their high biocompatibility. The development of biodegradable and biocompatible supramolecular polymers may offer a new choice for tissue regeneration application.
AB - A novel biodegradable supramolecular polymer (SMP) was successfully synthesized via self-complementary quadruple hydrogen bonding-driven poly(ε-caprolactone-co-δ-valerolactone)-b-poly(lactide) (PCVL-b-PLA) block copolymers. The SMP structure was analyzed by 1H NMR, GPC and the gel content, and found that the formation of self-complementary quadruple hydrogen bonds between UPy dimers not only expanded the polymer molecular chain, but also formed a cross-linked network structure for three-arm or four-arm branched PCVL-b-PLLA block copolymers. The results of WAXD and DSC indicated that compared with the precursor, the crystallization ability of supramolecular polymer was suppressed, but the stereocomplexation was conducive to the SMP crystallization. The tensile strength, elongation at break and tensile modulus were highly tunable and range from 7.1 ∼ 25.3 MPa, 588 ∼ 1860 % and 9.1 ∼ 21.4 MPa, respectively. The branching structure and sterecomplexation significantly adjusted the hydrophilicity and degradation of SMP. In addition, the synthesized SMP were evaluated for their biocompatibility by performing MTT assay using mouse fibroblasts (L929), indicating their high biocompatibility. The development of biodegradable and biocompatible supramolecular polymers may offer a new choice for tissue regeneration application.
KW - Poly(lactide)
KW - Stereocomplexation
KW - Supramolecular polymers
UR - http://www.scopus.com/inward/record.url?scp=85140892452&partnerID=8YFLogxK
U2 - 10.1016/j.eurpolymj.2022.111637
DO - 10.1016/j.eurpolymj.2022.111637
M3 - 文章
AN - SCOPUS:85140892452
SN - 0014-3057
VL - 181
JO - European Polymer Journal
JF - European Polymer Journal
M1 - 111637
ER -