Assessing the potential of an induced-mutation Strategy for avermectin overproducers

Hong Gao; Mei Liu; Ying Zhuo; Xianlong Zhou; Jintao Liu; Difei Chen; Wenquan Zhang; Zhongxuan Gou; Peng Shang; Lixin Zhang

doi:10.1128/AEM.01682-09

Assessing the potential of an induced-mutation Strategy for avermectin overproducers

Hong Gao, Mei Liu, Ying Zhuo, Xianlong Zhou, Jintao Liu, Difei Chen, Wenquan Zhang, Zhongxuan Gou, Peng Shang, Lixin Zhang

School of life sciences

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Mutant libraries of avermectin-producing Streptomyces avermitilis strains were constructed by different mutagenesis strategies. A metric was applied to assess the mutation spectrum by calculating the distribution of average phenotypic distance of each population. The results showed for the first time that a microgravity environment could introduce larger phenotype distribution and diversity than UV and N-methyl-N-nitro-Nnitrosoguanidine (NTG) could.

Original language	English
Pages (from-to)	4583-4586
Number of pages	4
Journal	Applied and Environmental Microbiology
Volume	76
Issue number	13
DOIs	https://doi.org/10.1128/AEM.01682-09
State	Published - Jul 2010

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abstract = "Mutant libraries of avermectin-producing Streptomyces avermitilis strains were constructed by different mutagenesis strategies. A metric was applied to assess the mutation spectrum by calculating the distribution of average phenotypic distance of each population. The results showed for the first time that a microgravity environment could introduce larger phenotype distribution and diversity than UV and N-methyl-N-nitro-Nnitrosoguanidine (NTG) could.",

author = "Hong Gao and Mei Liu and Ying Zhuo and Xianlong Zhou and Jintao Liu and Difei Chen and Wenquan Zhang and Zhongxuan Gou and Peng Shang and Lixin Zhang",

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AU - Gao, Hong

AU - Liu, Mei

AU - Zhuo, Ying

AU - Zhou, Xianlong

AU - Liu, Jintao

AU - Chen, Difei

AU - Zhang, Wenquan

AU - Gou, Zhongxuan

AU - Shang, Peng

AU - Zhang, Lixin

PY - 2010/7

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N2 - Mutant libraries of avermectin-producing Streptomyces avermitilis strains were constructed by different mutagenesis strategies. A metric was applied to assess the mutation spectrum by calculating the distribution of average phenotypic distance of each population. The results showed for the first time that a microgravity environment could introduce larger phenotype distribution and diversity than UV and N-methyl-N-nitro-Nnitrosoguanidine (NTG) could.

AB - Mutant libraries of avermectin-producing Streptomyces avermitilis strains were constructed by different mutagenesis strategies. A metric was applied to assess the mutation spectrum by calculating the distribution of average phenotypic distance of each population. The results showed for the first time that a microgravity environment could introduce larger phenotype distribution and diversity than UV and N-methyl-N-nitro-Nnitrosoguanidine (NTG) could.

UR - https://www.scopus.com/pages/publications/77954275046

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DO - 10.1128/AEM.01682-09

M3 - 文章

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AN - SCOPUS:77954275046

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ER -

Assessing the potential of an induced-mutation Strategy for avermectin overproducers

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