An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels

Ding Li; Xiaoping Li; Honglong Chang

doi:10.1109/MEMSYS.2018.8346775

An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels

Ding Li
, Xiaoping Li
, Honglong Chang

School of Mechanical Engineering

Northwestern Polytechnical University Xian

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

4 Scopus citations

Abstract

This paper reports an integrated ion chromatography microchip for the fast, low-cost and reproducible measurement of glycated hemoglobin (HbA_lc). Except the pump, all chromatography components including four membrane microvalves, a packed column, two porous frits and an optical detector cell are integrated on the single chip. In the experiments, the HbA_1c levels can be precisely measured with fewer samples (1 μl) in a shorter period of time (5 mins) compared to the state-of-the-art nanoflow liquid chromatography (LC) microchip (4 μl & 50 mins). The coefficient of variation (c.v.) for three consecutive measurements of HbA_1c calibrators was from 3.1% to 9.0%, indicating that the measurement was reproducible and the chip can be used for point-of-care diabetes diagnosis.

Original language	English
Title of host publication	2018 IEEE Micro Electro Mechanical Systems, MEMS 2018
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1189-1192
Number of pages	4
ISBN (Electronic)	9781538647820
DOIs	https://doi.org/10.1109/MEMSYS.2018.8346775
State	Published - 24 Apr 2018
Event	31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018 - Belfast, United Kingdom Duration: 21 Jan 2018 → 25 Jan 2018

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume	2018-January
ISSN (Print)	1084-6999

Conference

Conference	31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018
Country/Territory	United Kingdom
City	Belfast
Period	21/01/18 → 25/01/18

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1109/MEMSYS.2018.8346775

Cite this

Li, D., Li, X., & Chang, H. (2018). An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels. In 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018 (pp. 1189-1192). (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2018-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMSYS.2018.8346775

Li, Ding ; Li, Xiaoping ; Chang, Honglong. / An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels. 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Institute of Electrical and Electronics Engineers Inc., 2018. pp. 1189-1192 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

@inproceedings{2a8c3474d5504fe9bff9ea779ab58815,

title = "An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels",

abstract = "This paper reports an integrated ion chromatography microchip for the fast, low-cost and reproducible measurement of glycated hemoglobin (HbAlc). Except the pump, all chromatography components including four membrane microvalves, a packed column, two porous frits and an optical detector cell are integrated on the single chip. In the experiments, the HbA1c levels can be precisely measured with fewer samples (1 μl) in a shorter period of time (5 mins) compared to the state-of-the-art nanoflow liquid chromatography (LC) microchip (4 μl \& 50 mins). The coefficient of variation (c.v.) for three consecutive measurements of HbA1c calibrators was from 3.1\% to 9.0\%, indicating that the measurement was reproducible and the chip can be used for point-of-care diabetes diagnosis.",

author = "Ding Li and Xiaoping Li and Honglong Chang",

note = "Publisher Copyright: {\textcopyright} 2018 IEEE.; 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018 ; Conference date: 21-01-2018 Through 25-01-2018",

year = "2018",

month = apr,

day = "24",

doi = "10.1109/MEMSYS.2018.8346775",

language = "英语",

series = "Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "1189--1192",

booktitle = "2018 IEEE Micro Electro Mechanical Systems, MEMS 2018",

}

Li, D, Li, X & Chang, H 2018, An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels. in 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2018-January, Institute of Electrical and Electronics Engineers Inc., pp. 1189-1192, 31st IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2018, Belfast, United Kingdom, 21/01/18. https://doi.org/10.1109/MEMSYS.2018.8346775

An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels. / Li, Ding; Li, Xiaoping; Chang, Honglong.
2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Institute of Electrical and Electronics Engineers Inc., 2018. p. 1189-1192 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2018-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Li, Xiaoping

AU - Chang, Honglong

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N2 - This paper reports an integrated ion chromatography microchip for the fast, low-cost and reproducible measurement of glycated hemoglobin (HbAlc). Except the pump, all chromatography components including four membrane microvalves, a packed column, two porous frits and an optical detector cell are integrated on the single chip. In the experiments, the HbA1c levels can be precisely measured with fewer samples (1 μl) in a shorter period of time (5 mins) compared to the state-of-the-art nanoflow liquid chromatography (LC) microchip (4 μl & 50 mins). The coefficient of variation (c.v.) for three consecutive measurements of HbA1c calibrators was from 3.1% to 9.0%, indicating that the measurement was reproducible and the chip can be used for point-of-care diabetes diagnosis.

AB - This paper reports an integrated ion chromatography microchip for the fast, low-cost and reproducible measurement of glycated hemoglobin (HbAlc). Except the pump, all chromatography components including four membrane microvalves, a packed column, two porous frits and an optical detector cell are integrated on the single chip. In the experiments, the HbA1c levels can be precisely measured with fewer samples (1 μl) in a shorter period of time (5 mins) compared to the state-of-the-art nanoflow liquid chromatography (LC) microchip (4 μl & 50 mins). The coefficient of variation (c.v.) for three consecutive measurements of HbA1c calibrators was from 3.1% to 9.0%, indicating that the measurement was reproducible and the chip can be used for point-of-care diabetes diagnosis.

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PB - Institute of Electrical and Electronics Engineers Inc.

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ER -

Li D, Li X, Chang H. An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels. In 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018. Institute of Electrical and Electronics Engineers Inc. 2018. p. 1189-1192. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMSYS.2018.8346775

An integrated ion chromatography microchip for ultra fast measurement of glycated hemoglobin levels

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