Accelerated cellular on- and off-target screening of bioactive compounds using microarrays

Jiaqi Fu; Zhenkun Na; Bo Peng; Mahesh Uttamchandani; Shao Q. Yao

doi:10.1039/c5ob02233a

Accelerated cellular on- and off-target screening of bioactive compounds using microarrays

Jiaqi Fu
, Zhenkun Na
, Bo Peng
, Mahesh Uttamchandani
, Shao Q. Yao

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In situ proteome labeling was carried out with 9 drug-like probes in live mammalian cells, with the corresponding cellular targets captured on microarrays and simultaneously screened using a diverse set of antibodies, revealing potential on- and off-targets.

Original language	English
Pages (from-to)	59-64
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	14
Issue number	1
DOIs	https://doi.org/10.1039/c5ob02233a
State	Published - 2015
Externally published	Yes

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title = "Accelerated cellular on- and off-target screening of bioactive compounds using microarrays",

abstract = "In situ proteome labeling was carried out with 9 drug-like probes in live mammalian cells, with the corresponding cellular targets captured on microarrays and simultaneously screened using a diverse set of antibodies, revealing potential on- and off-targets.",

author = "Jiaqi Fu and Zhenkun Na and Bo Peng and Mahesh Uttamchandani and Yao, \{Shao Q.\}",

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AU - Fu, Jiaqi

AU - Na, Zhenkun

AU - Peng, Bo

AU - Uttamchandani, Mahesh

AU - Yao, Shao Q.

PY - 2015

Y1 - 2015

N2 - In situ proteome labeling was carried out with 9 drug-like probes in live mammalian cells, with the corresponding cellular targets captured on microarrays and simultaneously screened using a diverse set of antibodies, revealing potential on- and off-targets.

AB - In situ proteome labeling was carried out with 9 drug-like probes in live mammalian cells, with the corresponding cellular targets captured on microarrays and simultaneously screened using a diverse set of antibodies, revealing potential on- and off-targets.

UR - https://www.scopus.com/pages/publications/84983109279

U2 - 10.1039/c5ob02233a

DO - 10.1039/c5ob02233a

M3 - 文章

C2 - 26584520

AN - SCOPUS:84983109279

SN - 1477-0520

VL - 14

SP - 59

EP - 64

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 1

ER -

Accelerated cellular on- and off-target screening of bioactive compounds using microarrays

Abstract

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