A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage

Xingcan Huang; Qiang Zhang; Yawen Yang; Lung Chow; Jie Ma; Guoqiang Xu; Fang Guo; Xinxin He; Zhiyuan Li; Guangyao Zhao; Jingyou Su; Guihuan Guo; Jiachen Wang; Yanli Jiao; Zhan Gao; Jiyu Li; Jingkun Zhou; Chun Ki Yiu; Jian Li; Yi Chen; Pengcheng Wu; Kuanming Yao; Yiming Liu; Dengfeng Li; Binbin Zhang; Hongwei Chu; Yue Hu; Ya Huang; Zhenlin Chen; Kangning Ren; Bo Fang; Rungong Yang; Heng Li; Xiaoming Tao; Xiaohui Ma; Xinge Yu

doi:10.1038/s41467-025-61261-8

A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage

Xingcan Huang
, Qiang Zhang
, Yawen Yang
, Lung Chow
, Jie Ma
, Guoqiang Xu
, Fang Guo
, Xinxin He
, Zhiyuan Li
, Guangyao Zhao
, Jingyou Su
, Guihuan Guo
, Jiachen Wang
, Yanli Jiao
, Zhan Gao
, Jiyu Li
, Jingkun Zhou
, Chun Ki Yiu
, Jian Li
, Yi Chen

Pengcheng Wu, Kuanming Yao, Yiming Liu, Dengfeng Li, Binbin Zhang, Hongwei Chu, Yue Hu, Ya Huang, Zhenlin Chen, Kangning Ren, Bo Fang, Rungong Yang, Heng Li, Xiaoming Tao, Xiaohui Ma, Xinge Yu

City University of Hong Kong
Hong Kong Polytechnic University
The University of Hong Kong
Hong Kong Baptist University
New Territories
Sun Yat-Sen University
Sichuan University
Nursing Key Laboratory of Sichuan Province
Macau University of Science and Technology
Shenzhen University
Fudan University
General Hospital of People's Liberation Army
Shenzhen Research Institute of City University of Hong Kong

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management. This electronic bandage exhibits superior properties in multiple features and can be conformally adhered to the skin wound. In addition, the iSAFE can accurately assess the wound conditions in-situ and thus adaptively perform localized drug release. The results from both in vitro and in vivo studies on animals prove the validity of wound monitoring, wound healing boosting and intelligent closed-loop wound management. Clinical trials on patients across age 18 to 95 with various types of wounds are performed. These results all indicate the unique and universality of the reported technology for wound monitoring and management.

Original language	English
Article number	5782
Journal	Nature Communications
Volume	16
Issue number	1
DOIs	https://doi.org/10.1038/s41467-025-61261-8
State	Published - Dec 2025
Externally published	Yes

Access to Document

10.1038/s41467-025-61261-8

Cite this

Huang, X., Zhang, Q., Yang, Y., Chow, L., Ma, J., Xu, G., Guo, F., He, X., Li, Z., Zhao, G., Su, J., Guo, G., Wang, J., Jiao, Y., Gao, Z., Li, J., Zhou, J., Yiu, C. K., Li, J., ... Yu, X. (2025). A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage. Nature Communications, 16(1), Article 5782. https://doi.org/10.1038/s41467-025-61261-8

@article{1780b617883f43b1bbd49750312844b3,

title = "A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage",

abstract = "Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management. This electronic bandage exhibits superior properties in multiple features and can be conformally adhered to the skin wound. In addition, the iSAFE can accurately assess the wound conditions in-situ and thus adaptively perform localized drug release. The results from both in vitro and in vivo studies on animals prove the validity of wound monitoring, wound healing boosting and intelligent closed-loop wound management. Clinical trials on patients across age 18 to 95 with various types of wounds are performed. These results all indicate the unique and universality of the reported technology for wound monitoring and management.",

author = "Xingcan Huang and Qiang Zhang and Yawen Yang and Lung Chow and Jie Ma and Guoqiang Xu and Fang Guo and Xinxin He and Zhiyuan Li and Guangyao Zhao and Jingyou Su and Guihuan Guo and Jiachen Wang and Yanli Jiao and Zhan Gao and Jiyu Li and Jingkun Zhou and Yiu, \{Chun Ki\} and Jian Li and Yi Chen and Pengcheng Wu and Kuanming Yao and Yiming Liu and Dengfeng Li and Binbin Zhang and Hongwei Chu and Yue Hu and Ya Huang and Zhenlin Chen and Kangning Ren and Bo Fang and Rungong Yang and Heng Li and Xiaoming Tao and Xiaohui Ma and Xinge Yu",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2025",

month = dec,

doi = "10.1038/s41467-025-61261-8",

language = "英语",

volume = "16",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

number = "1",

}

Huang, X, Zhang, Q, Yang, Y, Chow, L, Ma, J, Xu, G, Guo, F, He, X, Li, Z, Zhao, G, Su, J, Guo, G, Wang, J, Jiao, Y, Gao, Z, Li, J, Zhou, J, Yiu, CK, Li, J, Chen, Y, Wu, P, Yao, K, Liu, Y, Li, D, Zhang, B, Chu, H, Hu, Y, Huang, Y, Chen, Z, Ren, K, Fang, B, Yang, R, Li, H, Tao, X, Ma, X & Yu, X 2025, 'A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage', Nature Communications, vol. 16, no. 1, 5782. https://doi.org/10.1038/s41467-025-61261-8

TY - JOUR

T1 - A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage

AU - Huang, Xingcan

AU - Zhang, Qiang

AU - Yang, Yawen

AU - Chow, Lung

AU - Ma, Jie

AU - Xu, Guoqiang

AU - Guo, Fang

AU - He, Xinxin

AU - Li, Zhiyuan

AU - Zhao, Guangyao

AU - Su, Jingyou

AU - Guo, Guihuan

AU - Wang, Jiachen

AU - Jiao, Yanli

AU - Gao, Zhan

AU - Li, Jiyu

AU - Zhou, Jingkun

AU - Yiu, Chun Ki

AU - Li, Jian

AU - Chen, Yi

AU - Wu, Pengcheng

AU - Yao, Kuanming

AU - Liu, Yiming

AU - Li, Dengfeng

AU - Zhang, Binbin

AU - Chu, Hongwei

AU - Hu, Yue

AU - Huang, Ya

AU - Chen, Zhenlin

AU - Ren, Kangning

AU - Fang, Bo

AU - Yang, Rungong

AU - Li, Heng

AU - Tao, Xiaoming

AU - Ma, Xiaohui

AU - Yu, Xinge

PY - 2025/12

Y1 - 2025/12

N2 - Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management. This electronic bandage exhibits superior properties in multiple features and can be conformally adhered to the skin wound. In addition, the iSAFE can accurately assess the wound conditions in-situ and thus adaptively perform localized drug release. The results from both in vitro and in vivo studies on animals prove the validity of wound monitoring, wound healing boosting and intelligent closed-loop wound management. Clinical trials on patients across age 18 to 95 with various types of wounds are performed. These results all indicate the unique and universality of the reported technology for wound monitoring and management.

AB - Chronic wound healing is a complex and long-standing problem, that has been a major and critical clinical concern around the world for years. Recent advances in digital wound dressings open new possibilities for solving the problem. Here, we report a battery-free, fully permeable, skin-adhesive, stretchable electronic wound bandage (iSAFE) for intelligent wound management. This electronic bandage exhibits superior properties in multiple features and can be conformally adhered to the skin wound. In addition, the iSAFE can accurately assess the wound conditions in-situ and thus adaptively perform localized drug release. The results from both in vitro and in vivo studies on animals prove the validity of wound monitoring, wound healing boosting and intelligent closed-loop wound management. Clinical trials on patients across age 18 to 95 with various types of wounds are performed. These results all indicate the unique and universality of the reported technology for wound monitoring and management.

UR - https://www.scopus.com/pages/publications/105009550772

U2 - 10.1038/s41467-025-61261-8

DO - 10.1038/s41467-025-61261-8

M3 - 文章

C2 - 40593825

AN - SCOPUS:105009550772

SN - 2041-1723

VL - 16

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 5782

ER -

A skin-interfaced three-dimensional closed-loop sensing and therapeutic electronic wound bandage

Abstract

Access to Document

Other files and links

Fingerprint

Cite this