A randomization and trial supply management system for adaptive clinical studies of TCM and its scientific research application in recurrent tuberculosis.

Tiancai Wen; Baoyan Liu; Liyun He; Xiaoying Lv; Xin Wang; Yanning Zhang

doi:10.1109/BIBM.2018.8621116

A randomization and trial supply management system for adaptive clinical studies of TCM and its scientific research application in recurrent tuberculosis.

Tiancai Wen
, Baoyan Liu
, Liyun He
, Xiaoying Lv
, Xin Wang
, Yanning Zhang

School of Computer Science

Northwestern Polytechnical University Xian
China Academy of Chinese Medical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

In recent years, a growing number of dynamic, double-blind and randomized trials for traditional Chinese medicine (TCM) have been designed with adaptive treatment regimens. The blind envelope or current randomization and trial supply management (RTSM) system have not met this requirement. Therefore, a more efficient platform for subject randomization and medicine dispensation was required. After we had done much research on dynamic TCM treatment trials' protocols, a new RTSM was designed and developed, which is suitable for TCM clinical trial during randomizing the groups for subject and medicine allocation in China. In a recurrent tuberculosis study of TCM, this RTSM system was involved in the management of subjects and medicines. By this system, a suit of TCM formulas or placeboes were assigned to patients based on their TCM syndrome diagnosis results by investigators at different visit points. The new RTSM system was convenient to operate, reduced operational errors, enhanced the management efficiency, and improved the data quality.

Original language	English
Title of host publication	Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
Editors	Harald Schmidt, David Griol, Haiying Wang, Jan Baumbach, Huiru Zheng, Zoraida Callejas, Xiaohua Hu, Julie Dickerson, Le Zhang
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1917-1921
Number of pages	5
ISBN (Electronic)	9781538654880
DOIs	https://doi.org/10.1109/BIBM.2018.8621116
State	Published - 21 Jan 2019
Event	2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 - Madrid, Spain Duration: 3 Dec 2018 → 6 Dec 2018

Publication series

Name	Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018

Conference

Conference	2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
Country/Territory	Spain
City	Madrid
Period	3/12/18 → 6/12/18

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

adaptive treatment regimens
randomization
recurrent tuberculosis
traditional Chinese medicine
trial supply management

Access to Document

10.1109/BIBM.2018.8621116

Cite this

Wen, T., Liu, B., He, L., Lv, X., Wang, X., & Zhang, Y. (2019). A randomization and trial supply management system for adaptive clinical studies of TCM and its scientific research application in recurrent tuberculosis. In H. Schmidt, D. Griol, H. Wang, J. Baumbach, H. Zheng, Z. Callejas, X. Hu, J. Dickerson, & L. Zhang (Eds.), Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 (pp. 1917-1921). Article 8621116 (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIBM.2018.8621116

Wen, Tiancai ; Liu, Baoyan ; He, Liyun et al. / A randomization and trial supply management system for adaptive clinical studies of TCM and its scientific research application in recurrent tuberculosis. Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. editor / Harald Schmidt ; David Griol ; Haiying Wang ; Jan Baumbach ; Huiru Zheng ; Zoraida Callejas ; Xiaohua Hu ; Julie Dickerson ; Le Zhang. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 1917-1921 (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018).

@inproceedings{c3724129c43f425b950ebf466b914322,

title = "A randomization and trial supply management system for adaptive clinical studies of TCM and its scientific research application in recurrent tuberculosis.",

abstract = "In recent years, a growing number of dynamic, double-blind and randomized trials for traditional Chinese medicine (TCM) have been designed with adaptive treatment regimens. The blind envelope or current randomization and trial supply management (RTSM) system have not met this requirement. Therefore, a more efficient platform for subject randomization and medicine dispensation was required. After we had done much research on dynamic TCM treatment trials' protocols, a new RTSM was designed and developed, which is suitable for TCM clinical trial during randomizing the groups for subject and medicine allocation in China. In a recurrent tuberculosis study of TCM, this RTSM system was involved in the management of subjects and medicines. By this system, a suit of TCM formulas or placeboes were assigned to patients based on their TCM syndrome diagnosis results by investigators at different visit points. The new RTSM system was convenient to operate, reduced operational errors, enhanced the management efficiency, and improved the data quality.",

keywords = "adaptive treatment regimens, randomization, recurrent tuberculosis, traditional Chinese medicine, trial supply management",

author = "Tiancai Wen and Baoyan Liu and Liyun He and Xiaoying Lv and Xin Wang and Yanning Zhang",

note = "Publisher Copyright: {\textcopyright} 2018 IEEE.; 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 ; Conference date: 03-12-2018 Through 06-12-2018",

year = "2019",

month = jan,

day = "21",

doi = "10.1109/BIBM.2018.8621116",

language = "英语",

series = "Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "1917--1921",

editor = "Harald Schmidt and David Griol and Haiying Wang and Jan Baumbach and Huiru Zheng and Zoraida Callejas and Xiaohua Hu and Julie Dickerson and Le Zhang",

booktitle = "Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018",

}

Wen, T, Liu, B, He, L, Lv, X, Wang, X & Zhang, Y 2019, A randomization and trial supply management system for adaptive clinical studies of TCM and its scientific research application in recurrent tuberculosis. in H Schmidt, D Griol, H Wang, J Baumbach, H Zheng, Z Callejas, X Hu, J Dickerson & L Zhang (eds), Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018., 8621116, Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018, Institute of Electrical and Electronics Engineers Inc., pp. 1917-1921, 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018, Madrid, Spain, 3/12/18. https://doi.org/10.1109/BIBM.2018.8621116

A randomization and trial supply management system for adaptive clinical studies of TCM and its scientific research application in recurrent tuberculosis. / Wen, Tiancai; Liu, Baoyan; He, Liyun et al.
Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. ed. / Harald Schmidt; David Griol; Haiying Wang; Jan Baumbach; Huiru Zheng; Zoraida Callejas; Xiaohua Hu; Julie Dickerson; Le Zhang. Institute of Electrical and Electronics Engineers Inc., 2019. p. 1917-1921 8621116 (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - A randomization and trial supply management system for adaptive clinical studies of TCM and its scientific research application in recurrent tuberculosis.

AU - Wen, Tiancai

AU - Liu, Baoyan

AU - He, Liyun

AU - Lv, Xiaoying

AU - Wang, Xin

AU - Zhang, Yanning

PY - 2019/1/21

Y1 - 2019/1/21

N2 - In recent years, a growing number of dynamic, double-blind and randomized trials for traditional Chinese medicine (TCM) have been designed with adaptive treatment regimens. The blind envelope or current randomization and trial supply management (RTSM) system have not met this requirement. Therefore, a more efficient platform for subject randomization and medicine dispensation was required. After we had done much research on dynamic TCM treatment trials' protocols, a new RTSM was designed and developed, which is suitable for TCM clinical trial during randomizing the groups for subject and medicine allocation in China. In a recurrent tuberculosis study of TCM, this RTSM system was involved in the management of subjects and medicines. By this system, a suit of TCM formulas or placeboes were assigned to patients based on their TCM syndrome diagnosis results by investigators at different visit points. The new RTSM system was convenient to operate, reduced operational errors, enhanced the management efficiency, and improved the data quality.

AB - In recent years, a growing number of dynamic, double-blind and randomized trials for traditional Chinese medicine (TCM) have been designed with adaptive treatment regimens. The blind envelope or current randomization and trial supply management (RTSM) system have not met this requirement. Therefore, a more efficient platform for subject randomization and medicine dispensation was required. After we had done much research on dynamic TCM treatment trials' protocols, a new RTSM was designed and developed, which is suitable for TCM clinical trial during randomizing the groups for subject and medicine allocation in China. In a recurrent tuberculosis study of TCM, this RTSM system was involved in the management of subjects and medicines. By this system, a suit of TCM formulas or placeboes were assigned to patients based on their TCM syndrome diagnosis results by investigators at different visit points. The new RTSM system was convenient to operate, reduced operational errors, enhanced the management efficiency, and improved the data quality.

KW - adaptive treatment regimens

KW - randomization

KW - recurrent tuberculosis

KW - traditional Chinese medicine

KW - trial supply management

UR - https://www.scopus.com/pages/publications/85062490118

U2 - 10.1109/BIBM.2018.8621116

DO - 10.1109/BIBM.2018.8621116

M3 - 会议稿件

AN - SCOPUS:85062490118

T3 - Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018

SP - 1917

EP - 1921

BT - Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018

A2 - Schmidt, Harald

A2 - Griol, David

A2 - Wang, Haiying

A2 - Baumbach, Jan

A2 - Zheng, Huiru

A2 - Callejas, Zoraida

A2 - Hu, Xiaohua

A2 - Dickerson, Julie

A2 - Zhang, Le

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018

Y2 - 3 December 2018 through 6 December 2018

ER -

Wen T, Liu B, He L, Lv X, Wang X, Zhang Y. A randomization and trial supply management system for adaptive clinical studies of TCM and its scientific research application in recurrent tuberculosis. In Schmidt H, Griol D, Wang H, Baumbach J, Zheng H, Callejas Z, Hu X, Dickerson J, Zhang L, editors, Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018. Institute of Electrical and Electronics Engineers Inc. 2019. p. 1917-1921. 8621116. (Proceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018). doi: 10.1109/BIBM.2018.8621116

A randomization and trial supply management system for adaptive clinical studies of TCM and its scientific research application in recurrent tuberculosis.

Abstract

Publication series

Conference

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this