A novel facile synthetic route to highly substituted 2,3-dihydrofurans via ammonium ylides

Zhanjun Yang, Mingjin Fan, Weimin Liu, Yongmin Liang

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Tetrasubstituted 2,3-dihydrofurans derivatives were prepared via the reaction of quaternary ammonium salts 1 with electrophilic alkenes 2 in the presence of powered K2CO3, usually in a stereoselective manner with good to high yields. The stereochemistry of dihydrofurans was secured by NMR signals and subsequently confirmed by X-ray diffraction.

Original languageEnglish
Pages (from-to)2188-2192
Number of pages5
JournalSynthesis
Issue number13
DOIs
StatePublished - 19 Aug 2005
Externally publishedYes

Keywords

  • 2,3-dihydrofurans
  • Alkenes
  • Ammonium ylides
  • Quaternary ammonium salts
  • Stereochemistry

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